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국내 B형 간염에 의한 간암 초기 환자에서의 혈장 DNA p53 유전자 Arg72Pro 다형성 및 exon 7 codon 249 돌연변이

Other Titles
 Arg72Pro Polymorphism and Exon 7 Codon 249 Mutation of Plasma DNA p53 Gene in Early Hepatocellular Carcinoma Patients with Hepatitis B Virus Infection in a Korean population 
Authors
 Yongjung Park  ;  Jong-Han Lee  ;  Eun Young Lee  ;  Hyon-Suk Kim 
Citation
 Journal of Laboratory Medicine and Quality Assurance (임상검사와 정도관리), Vol.32(2) : 255-262, 2010 
Journal Title
Journal of Laboratory Medicine and Quality Assurance(임상검사와 정도관리)
ISSN
 1225-097X 
Issue Date
2010
Keywords
Hepatocellular carcinoma ; p53 ; Hepatitis B virus ; Polymorphism
Abstract
Background: This study was performed to investigate on the genotypic frequencies
of p53 Arg72Pro polymorphism and the prevalence of p53 codon 249 mutation in
hepatocellular carcinoma patients.
Methods: Plasma DNAs were extracted from the samples of 44 early HCC cases,
24 chronic B-viral hepatitis patients and 27 healthy individuals. Serum levels of
AFP, PIVKA-II, and HBV DNA-positive rates among the study groups were also
compared. PCR-based restriction fragment length polymorphism method was used
to determine p53 Arg72Pro genotype and to detect codon 249 mutation.
Results: Serum AFP and PIVKA-II level, Edmondson grade, tumor size and
frequency of HBV DNA-positivity among HCC group according to Arg72Pro
genotypes showed no statistically significant difference. The frequencies of
Arg72Pro genotypes (Arg/Arg, Arg/Pro, Pro/Pro) were respectively as follows:
34.1%, 47.7%, 18.2% in HCC group; 29.2%, 54.2%, 16.7% in hepatitis group;
29.6%, 55.6%, 14.8% in control group. Pro homozygote genotype had a higher
risk for developing HCC by adjusted OR (1.529, 95% CI 0.325-7.193), but not
statistically significant (P=0.591). No codon 249 mutation was found among 44
HCC cases.
Conclusions: Pro homozygote was around 16% in all study groups, and did not
statistically increase risks to developing HCC. We suggest that Arg72Pro
polymorphism of p53 gene is not a significant risk factor in early
hepatocarcinogenesis
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Park, Yong Jung(박용정) ORCID logo https://orcid.org/0000-0001-5668-4120
Lee, Jong Han(이종한)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102985
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