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국내 B형 간염에 의한 간암 초기 환자에서의 혈장 DNA p53 유전자 Arg72Pro 다형성 및 exon 7 codon 249 돌연변이
DC Field | Value | Language |
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dc.contributor.author | 김현숙 | - |
dc.contributor.author | 박용정 | - |
dc.contributor.author | 이종한 | - |
dc.date.accessioned | 2015-04-23T17:42:46Z | - |
dc.date.available | 2015-04-23T17:42:46Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1225-097X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102985 | - |
dc.description.abstract | Background: This study was performed to investigate on the genotypic frequencies of p53 Arg72Pro polymorphism and the prevalence of p53 codon 249 mutation in hepatocellular carcinoma patients. Methods: Plasma DNAs were extracted from the samples of 44 early HCC cases, 24 chronic B-viral hepatitis patients and 27 healthy individuals. Serum levels of AFP, PIVKA-II, and HBV DNA-positive rates among the study groups were also compared. PCR-based restriction fragment length polymorphism method was used to determine p53 Arg72Pro genotype and to detect codon 249 mutation. Results: Serum AFP and PIVKA-II level, Edmondson grade, tumor size and frequency of HBV DNA-positivity among HCC group according to Arg72Pro genotypes showed no statistically significant difference. The frequencies of Arg72Pro genotypes (Arg/Arg, Arg/Pro, Pro/Pro) were respectively as follows: 34.1%, 47.7%, 18.2% in HCC group; 29.2%, 54.2%, 16.7% in hepatitis group; 29.6%, 55.6%, 14.8% in control group. Pro homozygote genotype had a higher risk for developing HCC by adjusted OR (1.529, 95% CI 0.325-7.193), but not statistically significant (P=0.591). No codon 249 mutation was found among 44 HCC cases. Conclusions: Pro homozygote was around 16% in all study groups, and did not statistically increase risks to developing HCC. We suggest that Arg72Pro polymorphism of p53 gene is not a significant risk factor in early hepatocarcinogenesis | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 255~262 | - |
dc.relation.isPartOf | Journal of Laboratory Medicine and Quality Assurance (임상검사와 정도관리) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 국내 B형 간염에 의한 간암 초기 환자에서의 혈장 DNA p53 유전자 Arg72Pro 다형성 및 exon 7 codon 249 돌연변이 | - |
dc.title.alternative | Arg72Pro Polymorphism and Exon 7 Codon 249 Mutation of Plasma DNA p53 Gene in Early Hepatocellular Carcinoma Patients with Hepatitis B Virus Infection in a Korean population | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Yongjung Park | - |
dc.contributor.googleauthor | Jong-Han Lee | - |
dc.contributor.googleauthor | Eun Young Lee | - |
dc.contributor.googleauthor | Hyon-Suk Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01582 | - |
dc.contributor.localId | A03151 | - |
dc.contributor.localId | A01117 | - |
dc.relation.journalcode | J01555 | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | p53 | - |
dc.subject.keyword | Hepatitis B virus | - |
dc.subject.keyword | Polymorphism | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.alternativeName | Park, Yong Jung | - |
dc.contributor.alternativeName | Lee, Jong Han | - |
dc.contributor.affiliatedAuthor | Park, Yong Jung | - |
dc.contributor.affiliatedAuthor | Lee, Jong Han | - |
dc.contributor.affiliatedAuthor | Kim, Hyon Suk | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 255 | - |
dc.citation.endPage | 262 | - |
dc.identifier.bibliographicCitation | Journal of Laboratory Medicine and Quality Assurance (임상검사와 정도관리), Vol.32(2) : 255-262, 2010 | - |
dc.identifier.rimsid | 35140 | - |
dc.type.rims | ART | - |
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