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국내 B형 간염에 의한 간암 초기 환자에서의 혈장 DNA p53 유전자 Arg72Pro 다형성 및 exon 7 codon 249 돌연변이

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dc.contributor.author김현숙-
dc.contributor.author박용정-
dc.contributor.author이종한-
dc.date.accessioned2015-04-23T17:42:46Z-
dc.date.available2015-04-23T17:42:46Z-
dc.date.issued2010-
dc.identifier.issn1225-097X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102985-
dc.description.abstractBackground: This study was performed to investigate on the genotypic frequencies of p53 Arg72Pro polymorphism and the prevalence of p53 codon 249 mutation in hepatocellular carcinoma patients. Methods: Plasma DNAs were extracted from the samples of 44 early HCC cases, 24 chronic B-viral hepatitis patients and 27 healthy individuals. Serum levels of AFP, PIVKA-II, and HBV DNA-positive rates among the study groups were also compared. PCR-based restriction fragment length polymorphism method was used to determine p53 Arg72Pro genotype and to detect codon 249 mutation. Results: Serum AFP and PIVKA-II level, Edmondson grade, tumor size and frequency of HBV DNA-positivity among HCC group according to Arg72Pro genotypes showed no statistically significant difference. The frequencies of Arg72Pro genotypes (Arg/Arg, Arg/Pro, Pro/Pro) were respectively as follows: 34.1%, 47.7%, 18.2% in HCC group; 29.2%, 54.2%, 16.7% in hepatitis group; 29.6%, 55.6%, 14.8% in control group. Pro homozygote genotype had a higher risk for developing HCC by adjusted OR (1.529, 95% CI 0.325-7.193), but not statistically significant (P=0.591). No codon 249 mutation was found among 44 HCC cases. Conclusions: Pro homozygote was around 16% in all study groups, and did not statistically increase risks to developing HCC. We suggest that Arg72Pro polymorphism of p53 gene is not a significant risk factor in early hepatocarcinogenesis-
dc.description.statementOfResponsibilityopen-
dc.format.extent255~262-
dc.relation.isPartOfJournal of Laboratory Medicine and Quality Assurance (임상검사와 정도관리)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title국내 B형 간염에 의한 간암 초기 환자에서의 혈장 DNA p53 유전자 Arg72Pro 다형성 및 exon 7 codon 249 돌연변이-
dc.title.alternativeArg72Pro Polymorphism and Exon 7 Codon 249 Mutation of Plasma DNA p53 Gene in Early Hepatocellular Carcinoma Patients with Hepatitis B Virus Infection in a Korean population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorYongjung Park-
dc.contributor.googleauthorJong-Han Lee-
dc.contributor.googleauthorEun Young Lee-
dc.contributor.googleauthorHyon-Suk Kim-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01582-
dc.contributor.localIdA03151-
dc.contributor.localIdA01117-
dc.relation.journalcodeJ01555-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordp53-
dc.subject.keywordHepatitis B virus-
dc.subject.keywordPolymorphism-
dc.contributor.alternativeNameKim, Hyon Suk-
dc.contributor.alternativeNamePark, Yong Jung-
dc.contributor.alternativeNameLee, Jong Han-
dc.contributor.affiliatedAuthorPark, Yong Jung-
dc.contributor.affiliatedAuthorLee, Jong Han-
dc.contributor.affiliatedAuthorKim, Hyon Suk-
dc.citation.volume32-
dc.citation.number2-
dc.citation.startPage255-
dc.citation.endPage262-
dc.identifier.bibliographicCitationJournal of Laboratory Medicine and Quality Assurance (임상검사와 정도관리), Vol.32(2) : 255-262, 2010-
dc.identifier.rimsid35140-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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