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The clinical outcome of chemotherapy-induced amenorrhea in premenopausal young patients with breast cancer with long-term follow-up

 Minkyu Jung  ;  Hyun Joon Shin  ;  Sun Young Rha  ;  Hei Cheul Jeung  ;  Soojung Hong  ;  Yong Wha Moon  ;  Hyo Song Kim  ;  Kyung Jin Oh  ;  Woo Ick Yang  ;  Jae Kyung Roh  ;  Hyun Cheol Chung 
 ANNALS OF SURGICAL ONCOLOGY, Vol.17(12) : 3259-3268, 2010 
Journal Title
Issue Date
Adult ; Amenorrhea/chemically induced* ; Amenorrhea/drug therapy ; Antineoplastic Agents, Hormonal/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects* ; Breast Neoplasms/drug therapy* ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/drug therapy* ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Lobular/drug therapy* ; Carcinoma, Lobular/pathology ; Cyclophosphamide/adverse effects ; Doxorubicin/adverse effects ; Female ; Fluorouracil/adverse effects ; Follow-Up Studies ; Humans ; Methotrexate/adverse effects ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Premenopause ; Survival Rate ; Tamoxifen/adverse effects* ; Treatment Outcome
BACKGROUND: We investigated the factors that predict chemotherapy-induced amenorrhea (CIA) and the prognostic significance of CIA after long-term follow-up.

METHODS: We reviewed data from 241 premenopausal patients with breast cancer who underwent adjuvant CMF or FAC chemotherapy after breast cancer surgery between January 1995 and December 2000.

RESULTS: The median follow-up duration was 109.8 (range, 16.6-193.1) months. The age of CIA patients was older than non-CIA patients (median, 44 (range, 28-53) years and 36 (range, 25-49) years, respectively; P < 0.001). The addition of tamoxifen to the chemotherapy increased the incidence of CIA from 48% to 63.6% (P = 0.015). The 10-year disease-free survival (DFS) rate was higher in the CIA group compared with the non-CIA group in hormonal receptor-positive patients (78.4% vs. 67%, respectively; P = 0.022), and the 10-year overall survival (OS) rate also was higher in the CIA group compared with the non-CIA group (90.8% vs. 79.7%, respectively; P = 0.041).

CONCLUSIONS: The most important predictors of CIA are age and the addition of tamoxifen to the chemotherapy. CIA is likely to have an influence on DFS and OS in premenopausal patients with breast cancer with a positive hormone receptor, and it might be used as a surrogate marker for effective chemotherapy in these young Asian patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyo Song(김효송) ORCID logo https://orcid.org/0000-0002-0625-9828
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Moon, Yong Wha(문용화)
Shin, Hyun Joon(신현준)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Jung, Min Kyu(정민규) ORCID logo https://orcid.org/0000-0001-8281-3387
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
Hong, Soo Jung(홍수정)
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