Cited 43 times in
The clinical outcome of chemotherapy-induced amenorrhea in premenopausal young patients with breast cancer with long-term follow-up
DC Field | Value | Language |
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dc.contributor.author | 김효송 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 문용화 | - |
dc.contributor.author | 신현준 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 정민규 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.contributor.author | 홍수정 | - |
dc.date.accessioned | 2015-04-23T17:29:58Z | - |
dc.date.available | 2015-04-23T17:29:58Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102581 | - |
dc.description.abstract | BACKGROUND: We investigated the factors that predict chemotherapy-induced amenorrhea (CIA) and the prognostic significance of CIA after long-term follow-up. METHODS: We reviewed data from 241 premenopausal patients with breast cancer who underwent adjuvant CMF or FAC chemotherapy after breast cancer surgery between January 1995 and December 2000. RESULTS: The median follow-up duration was 109.8 (range, 16.6-193.1) months. The age of CIA patients was older than non-CIA patients (median, 44 (range, 28-53) years and 36 (range, 25-49) years, respectively; P < 0.001). The addition of tamoxifen to the chemotherapy increased the incidence of CIA from 48% to 63.6% (P = 0.015). The 10-year disease-free survival (DFS) rate was higher in the CIA group compared with the non-CIA group in hormonal receptor-positive patients (78.4% vs. 67%, respectively; P = 0.022), and the 10-year overall survival (OS) rate also was higher in the CIA group compared with the non-CIA group (90.8% vs. 79.7%, respectively; P = 0.041). CONCLUSIONS: The most important predictors of CIA are age and the addition of tamoxifen to the chemotherapy. CIA is likely to have an influence on DFS and OS in premenopausal patients with breast cancer with a positive hormone receptor, and it might be used as a surrogate marker for effective chemotherapy in these young Asian patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3259~3268 | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Amenorrhea/chemically induced* | - |
dc.subject.MESH | Amenorrhea/drug therapy | - |
dc.subject.MESH | Antineoplastic Agents, Hormonal/adverse effects | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/adverse effects* | - |
dc.subject.MESH | Breast Neoplasms/drug therapy* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/drug therapy* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/pathology | - |
dc.subject.MESH | Carcinoma, Lobular/drug therapy* | - |
dc.subject.MESH | Carcinoma, Lobular/pathology | - |
dc.subject.MESH | Cyclophosphamide/adverse effects | - |
dc.subject.MESH | Doxorubicin/adverse effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorouracil/adverse effects | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Methotrexate/adverse effects | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/drug therapy | - |
dc.subject.MESH | Neoplasm Recurrence, Local/pathology | - |
dc.subject.MESH | Premenopause | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Tamoxifen/adverse effects* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | The clinical outcome of chemotherapy-induced amenorrhea in premenopausal young patients with breast cancer with long-term follow-up | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Minkyu Jung | - |
dc.contributor.googleauthor | Hyun Joon Shin | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Hei Cheul Jeung | - |
dc.contributor.googleauthor | Soojung Hong | - |
dc.contributor.googleauthor | Yong Wha Moon | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.contributor.googleauthor | Kyung Jin Oh | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Jae Kyung Roh | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.identifier.doi | 10.1245/s10434-010-1172-3 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01370 | - |
dc.contributor.localId | A02179 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A03606 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A04410 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 20563656 | - |
dc.identifier.url | http://link.springer.com/article/10.1245%2Fs10434-010-1172-3 | - |
dc.contributor.alternativeName | Kim, Hyo Song | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Moon, Yong Wha | - |
dc.contributor.alternativeName | Shin, Hyun Joon | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Jung, Min Kyu | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.alternativeName | Hong, Soo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Song | - |
dc.contributor.affiliatedAuthor | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | Moon, Yong Wha | - |
dc.contributor.affiliatedAuthor | Shin, Hyun Joon | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Jung, Min Kyu | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Hong, Soo Jung | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.citation.volume | 17 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3259 | - |
dc.citation.endPage | 3268 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.17(12) : 3259-3268, 2010 | - |
dc.identifier.rimsid | 55308 | - |
dc.type.rims | ART | - |
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