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Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging.

Authors
 Eun-Kyung Lim  ;  Jaemoon Yang  ;  Colin P.N. Dinney  ;  Jin-Suck Suh  ;  Yong-Min Huh  ;  Seungjoo Haam 
Citation
 BIOMATERIALS, Vol.31(35) : 9310-9319, 2010 
Journal Title
BIOMATERIALS
ISSN
 0142-9612 
Issue Date
2010
MeSH
Animals ; Cell Line ; Cell Line, Tumor ; Fluorescence ; Magnetic Resonance Imaging/instrumentation* ; Magnetics ; Male ; Manganese Compounds/chemistry ; Mice ; Microscopy, Fluorescence ; Models, Theoretical ; Nanoparticles/chemistry* ; Nanotechnology/instrumentation* ; Nanotechnology/methods ; Polyethylene Glycols/chemistry
Keywords
Nanoprobe ; Magnetic resonance imaging ; Multimode ; Fluorescent
Abstract
We fabricated multimode nanoprobes for acquisition of biological information at different object levels, i.e., in vivo detection and ex vivo validation for characterizing tumor angiogenesis. Fluorescent magnetic nanoprobes (FMNPs) were synthesized by using amphiphilic pyrenyl polyethylene glycol (Py-PEG) and superparamagnetic MnFe(2)O(4) nanocrystals (MNCs). Py-PEG, which is synthesized by conjugation of hydrophilic PEG with hydrophobic and fluorescent 1-pyrenebutyric acid through an esterification process, is capable of self-assembly and maintaining a high UV fluorescent intensity in aqueous phase. Py-PEG can be used as a fluorescent surfactant that simultaneously and efficiently encapsulates MNCs to exhibit fluorescent and magnetic properties as well as maintaining high water-solubility. Consequently, we proved that our biologically non-toxic FMNPs were prominent multimode imaging probes by showing not only excellent MR sensitivity but also high illumination intensity with strong signal strength under short exposure time of UV light from the extensive imaging studies of in vitro/vivo and ex vivo using orthotopic and xenograft mice models
Full Text
http://www.sciencedirect.com/science/article/pii/S0142961210009531
DOI
10.1016/j.biomaterials.2010.07.081
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102523
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