1 309

Cited 50 times in

Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging.

DC Field Value Language
dc.contributor.author서진석-
dc.contributor.author양재문-
dc.contributor.author허용민-
dc.date.accessioned2015-04-23T17:28:11Z-
dc.date.available2015-04-23T17:28:11Z-
dc.date.issued2010-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102523-
dc.description.abstractWe fabricated multimode nanoprobes for acquisition of biological information at different object levels, i.e., in vivo detection and ex vivo validation for characterizing tumor angiogenesis. Fluorescent magnetic nanoprobes (FMNPs) were synthesized by using amphiphilic pyrenyl polyethylene glycol (Py-PEG) and superparamagnetic MnFe(2)O(4) nanocrystals (MNCs). Py-PEG, which is synthesized by conjugation of hydrophilic PEG with hydrophobic and fluorescent 1-pyrenebutyric acid through an esterification process, is capable of self-assembly and maintaining a high UV fluorescent intensity in aqueous phase. Py-PEG can be used as a fluorescent surfactant that simultaneously and efficiently encapsulates MNCs to exhibit fluorescent and magnetic properties as well as maintaining high water-solubility. Consequently, we proved that our biologically non-toxic FMNPs were prominent multimode imaging probes by showing not only excellent MR sensitivity but also high illumination intensity with strong signal strength under short exposure time of UV light from the extensive imaging studies of in vitro/vivo and ex vivo using orthotopic and xenograft mice models-
dc.description.statementOfResponsibilityopen-
dc.format.extent9310~9319-
dc.relation.isPartOfBIOMATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Line-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHFluorescence-
dc.subject.MESHMagnetic Resonance Imaging/instrumentation*-
dc.subject.MESHMagnetics-
dc.subject.MESHMale-
dc.subject.MESHManganese Compounds/chemistry-
dc.subject.MESHMice-
dc.subject.MESHMicroscopy, Fluorescence-
dc.subject.MESHModels, Theoretical-
dc.subject.MESHNanoparticles/chemistry*-
dc.subject.MESHNanotechnology/instrumentation*-
dc.subject.MESHNanotechnology/methods-
dc.subject.MESHPolyethylene Glycols/chemistry-
dc.titleSelf-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorEun-Kyung Lim-
dc.contributor.googleauthorJaemoon Yang-
dc.contributor.googleauthorColin P.N. Dinney-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorSeungjoo Haam-
dc.identifier.doi10.1016/j.biomaterials.2010.07.081-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02315-
dc.contributor.localIdA01916-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ00312-
dc.identifier.eissn1878-5905-
dc.identifier.pmid20851463-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0142961210009531-
dc.subject.keywordNanoprobe-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordMultimode-
dc.subject.keywordFluorescent-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorYang, Jae Moon-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.citation.volume31-
dc.citation.number35-
dc.citation.startPage9310-
dc.citation.endPage9319-
dc.identifier.bibliographicCitationBIOMATERIALS, Vol.31(35) : 9310-9319, 2010-
dc.identifier.rimsid49812-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.