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Relationship between the diagnostic components of metabolic syndrome (MS) and cognition by ApoE genotype in the elderly

Authors
 Kang Soo Lee  ;  Yangsoo Jang  ;  Young-Ki Chunge  ;  Ji Hyung Chung  ;  Byoung Hoon Oh  ;  Chang Hyung Hong 
Citation
 ARCHIVES OF GERONTOLOGY AND GERIATRICS, Vol.50(1) : 69-72, 2010 
Journal Title
 ARCHIVES OF GERONTOLOGY AND GERIATRICS 
ISSN
 0167-4943 
Issue Date
2010
MeSH
Age Distribution ; Aged ; Aged, 80 and over ; Aging/genetics ; Aging/physiology ; Apolipoproteins E/genetics* ; Cognition Disorders/diagnosis* ; Cognition Disorders/epidemiology ; Cognition Disorders/genetics* ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease/epidemiology* ; Genotype ; Geriatric Assessment ; Humans ; Incidence ; Logistic Models ; Longitudinal Studies ; Male ; Metabolic Syndrome/diagnosis* ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/genetics* ; Middle Aged ; Multivariate Analysis ; Probability ; Registries ; Risk Assessment ; Sex Distribution
Keywords
Metabolic syndrome ; Cognitive impairment ; Mini-mental state examination ; ApoE genotype in the elderly
Abstract
The purpose of this study was to find out the effect of the ApoE genotype on the relationship between metabolic syndrome (MS) and its diagnostic components and cognitive impairment in the elderly. A total of 2944 subjects aged over 60 years were analyzed from the data of Gwangju Dementia and Mild Cognitive Impairment Study. We examined demographic characteristics, current and past illness history, drug history, Korean version-mini-mental state examination (K-MMSE). We also examined ApoE genotype and analyzed associated factors with MS. The MS was present in 53.8% of the subjects (36.8% of men and 61.1% of women). On multiple logistic regression analysis, MS was not associated with the cognitive impairment (K-MMSE score <18) adjusted for age, sex, and educational level. The interactive effect between systolic and diastolic blood pressure (SBP, and DBP, respectively) and ApoE on cognition was not significant (all p>0.3), but the interactive effect between triglyceride (TG), high-density-lipoprotein-cholesterol (HDLc) and ApoE on cognition was significant after adjustment for age, sex, and education (B=-0.285, Wald=4.194, p=0.041; B=0.372, Wald=4.134, p=0.042). These results suggest that blood TG and HDLc may affect cognitive function in the elderly in the presence of ApoE varepsilon4 allele.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167494309000387
DOI
10.1016/j.archger.2009.01.014
Appears in Collections:
5. Research Institutes (연구소) > Cardiovascular Product Evaluation Center (심혈관제품유효성평가센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Byong Hoon(오병훈)
Lee, Kang Soo(이강수)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Ji Hyung(정지형)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102518
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