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The biological activities of (1,3)-(1,6)-beta-d-glucan and porous electrospun PLGA membranes containing beta-glucan in human dermal fibroblasts and adipose tissue-derived stem cells

 Yeon I Woo  ;  Bong Joo Park  ;  Hye-Lee Kim  ;  Mi Hee Lee  ;  Jungsung Kim  ;  Young-Il Yang  ;  Jung Koo Kim  ;  Kazufumi Tsubaki  ;  Dong-Wook Han  ;  Jong-Chul Park 
 BIOMEDICAL MATERIALS, Vol.5(4) : 044109, 2010 
Journal Title
Issue Date
Adipose Tissue/cytology* ; Adipose Tissue/physiology ; Biological Dressings* ; Cell Culture Techniques/methods ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Electrochemistry/methods ; Fibroblasts/cytology* ; Fibroblasts/physiology ; Glucans/chemistry* ; Lactic Acid/chemistry* ; Membranes, Artificial* ; Polyglycolic Acid/chemistry* ; Porosity ; Rotation ; Skin/cytology ; Skin Physiological Phenomena ; Stem Cells/cytology* ; Stem Cells/physiology ; Tissue Engineering/instrumentation ; Wound Healing/physiology
In this study, we investigated the possible roles of (1,3)-(1,6)-beta-d-glucan (beta-glucan) and porous electrospun poly-lactide-co-glycolide (PLGA) membranes containing beta-glucan for skin wound healing, especially their effect on adult human dermal fibroblast (aHDF) and adipose tissue-derived stem cell (ADSC) activation, proliferation, migration, collagen gel contraction and biological safety tests of the prepared membrane. This study demonstrated that beta-glucan and porous PLGA membranes containing beta-glucan have enhanced the cellular responses, proliferation and migration, of aHDFs and ADSCs and the result of a collagen gel contraction assay also revealed that collagen gels contract strongly after 4 h post-gelation incubation with beta-glucan. Furthermore, we confirmed that porous PLGA membranes containing beta-glucan are biologically safe for wound healing study. These results indicate that the porous PLGA membranes containing beta-glucan interacted favorably with the membrane and the topical administration of beta-glucan was useful in promoting wound healing. Therefore, our study suggests that beta-glucan and porous PLGA membranes containing beta-glucan may be useful as a material for enhancing wound healing
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1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Lee(김혜리)
Park, Bong Joo(박봉주)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Woo, Yeon I.(우연이)
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
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