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The biological activities of (1,3)-(1,6)-beta-d-glucan and porous electrospun PLGA membranes containing beta-glucan in human dermal fibroblasts and adipose tissue-derived stem cells

DC FieldValueLanguage
dc.contributor.author김혜리-
dc.contributor.author박봉주-
dc.contributor.author박종철-
dc.contributor.author우연이-
dc.contributor.author이미희-
dc.date.accessioned2015-04-23T17:21:11Z-
dc.date.available2015-04-23T17:21:11Z-
dc.date.issued2010-
dc.identifier.issn1748-6041-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102299-
dc.description.abstractIn this study, we investigated the possible roles of (1,3)-(1,6)-beta-d-glucan (beta-glucan) and porous electrospun poly-lactide-co-glycolide (PLGA) membranes containing beta-glucan for skin wound healing, especially their effect on adult human dermal fibroblast (aHDF) and adipose tissue-derived stem cell (ADSC) activation, proliferation, migration, collagen gel contraction and biological safety tests of the prepared membrane. This study demonstrated that beta-glucan and porous PLGA membranes containing beta-glucan have enhanced the cellular responses, proliferation and migration, of aHDFs and ADSCs and the result of a collagen gel contraction assay also revealed that collagen gels contract strongly after 4 h post-gelation incubation with beta-glucan. Furthermore, we confirmed that porous PLGA membranes containing beta-glucan are biologically safe for wound healing study. These results indicate that the porous PLGA membranes containing beta-glucan interacted favorably with the membrane and the topical administration of beta-glucan was useful in promoting wound healing. Therefore, our study suggests that beta-glucan and porous PLGA membranes containing beta-glucan may be useful as a material for enhancing wound healing-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBIOMEDICAL MATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdipose Tissue/cytology*-
dc.subject.MESHAdipose Tissue/physiology-
dc.subject.MESHBiological Dressings*-
dc.subject.MESHCell Culture Techniques/methods-
dc.subject.MESHCell Differentiation-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCells, Cultured-
dc.subject.MESHElectrochemistry/methods-
dc.subject.MESHFibroblasts/cytology*-
dc.subject.MESHFibroblasts/physiology-
dc.subject.MESHGlucans/chemistry*-
dc.subject.MESHLactic Acid/chemistry*-
dc.subject.MESHMembranes, Artificial*-
dc.subject.MESHPolyglycolic Acid/chemistry*-
dc.subject.MESHPorosity-
dc.subject.MESHRotation-
dc.subject.MESHSkin/cytology-
dc.subject.MESHSkin Physiological Phenomena-
dc.subject.MESHStem Cells/cytology*-
dc.subject.MESHStem Cells/physiology-
dc.subject.MESHTissue Engineering/instrumentation-
dc.subject.MESHWound Healing/physiology-
dc.titleThe biological activities of (1,3)-(1,6)-beta-d-glucan and porous electrospun PLGA membranes containing beta-glucan in human dermal fibroblasts and adipose tissue-derived stem cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentMedical Research Center (임상의학연구센터)-
dc.contributor.googleauthorYeon I Woo-
dc.contributor.googleauthorBong Joo Park-
dc.contributor.googleauthorHye-Lee Kim-
dc.contributor.googleauthorMi Hee Lee-
dc.contributor.googleauthorJungsung Kim-
dc.contributor.googleauthorYoung-Il Yang-
dc.contributor.googleauthorJung Koo Kim-
dc.contributor.googleauthorKazufumi Tsubaki-
dc.contributor.googleauthorDong-Wook Han-
dc.contributor.googleauthorJong-Chul Park-
dc.identifier.doi10.1088/1748-6041/5/4/044109-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01169-
dc.contributor.localIdA01482-
dc.contributor.localIdA01662-
dc.contributor.localIdA02426-
dc.contributor.localIdA02777-
dc.relation.journalcodeJ00318-
dc.identifier.eissn1748-605X-
dc.identifier.pmid20683126-
dc.identifier.urlhttp://iopscience.iop.org/1748-605X/5/4/044109/-
dc.contributor.alternativeNameKim, Hye Lee-
dc.contributor.alternativeNamePark, Bong Joo-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.alternativeNameWoo, Yeon I.-
dc.contributor.alternativeNameLee, Mi Hee-
dc.contributor.affiliatedAuthorKim, Hye Lee-
dc.contributor.affiliatedAuthorPark, Bong Joo-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.contributor.affiliatedAuthorWoo, Yeon I.-
dc.contributor.affiliatedAuthorLee, Mi Hee-
dc.citation.volume5-
dc.citation.number4-
dc.citation.startPage044109-
dc.identifier.bibliographicCitationBIOMEDICAL MATERIALS, Vol.5(4) : 044109, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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