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The biological activities of (1,3)-(1,6)-beta-d-glucan and porous electrospun PLGA membranes containing beta-glucan in human dermal fibroblasts and adipose tissue-derived stem cells
DC Field | Value | Language |
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dc.contributor.author | 김혜리 | - |
dc.contributor.author | 박봉주 | - |
dc.contributor.author | 박종철 | - |
dc.contributor.author | 우연이 | - |
dc.contributor.author | 이미희 | - |
dc.date.accessioned | 2015-04-23T17:21:11Z | - |
dc.date.available | 2015-04-23T17:21:11Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1748-6041 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102299 | - |
dc.description.abstract | In this study, we investigated the possible roles of (1,3)-(1,6)-beta-d-glucan (beta-glucan) and porous electrospun poly-lactide-co-glycolide (PLGA) membranes containing beta-glucan for skin wound healing, especially their effect on adult human dermal fibroblast (aHDF) and adipose tissue-derived stem cell (ADSC) activation, proliferation, migration, collagen gel contraction and biological safety tests of the prepared membrane. This study demonstrated that beta-glucan and porous PLGA membranes containing beta-glucan have enhanced the cellular responses, proliferation and migration, of aHDFs and ADSCs and the result of a collagen gel contraction assay also revealed that collagen gels contract strongly after 4 h post-gelation incubation with beta-glucan. Furthermore, we confirmed that porous PLGA membranes containing beta-glucan are biologically safe for wound healing study. These results indicate that the porous PLGA membranes containing beta-glucan interacted favorably with the membrane and the topical administration of beta-glucan was useful in promoting wound healing. Therefore, our study suggests that beta-glucan and porous PLGA membranes containing beta-glucan may be useful as a material for enhancing wound healing | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOMEDICAL MATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipose Tissue/cytology* | - |
dc.subject.MESH | Adipose Tissue/physiology | - |
dc.subject.MESH | Biological Dressings* | - |
dc.subject.MESH | Cell Culture Techniques/methods | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Electrochemistry/methods | - |
dc.subject.MESH | Fibroblasts/cytology* | - |
dc.subject.MESH | Fibroblasts/physiology | - |
dc.subject.MESH | Glucans/chemistry* | - |
dc.subject.MESH | Lactic Acid/chemistry* | - |
dc.subject.MESH | Membranes, Artificial* | - |
dc.subject.MESH | Polyglycolic Acid/chemistry* | - |
dc.subject.MESH | Porosity | - |
dc.subject.MESH | Rotation | - |
dc.subject.MESH | Skin/cytology | - |
dc.subject.MESH | Skin Physiological Phenomena | - |
dc.subject.MESH | Stem Cells/cytology* | - |
dc.subject.MESH | Stem Cells/physiology | - |
dc.subject.MESH | Tissue Engineering/instrumentation | - |
dc.subject.MESH | Wound Healing/physiology | - |
dc.title | The biological activities of (1,3)-(1,6)-beta-d-glucan and porous electrospun PLGA membranes containing beta-glucan in human dermal fibroblasts and adipose tissue-derived stem cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Yeon I Woo | - |
dc.contributor.googleauthor | Bong Joo Park | - |
dc.contributor.googleauthor | Hye-Lee Kim | - |
dc.contributor.googleauthor | Mi Hee Lee | - |
dc.contributor.googleauthor | Jungsung Kim | - |
dc.contributor.googleauthor | Young-Il Yang | - |
dc.contributor.googleauthor | Jung Koo Kim | - |
dc.contributor.googleauthor | Kazufumi Tsubaki | - |
dc.contributor.googleauthor | Dong-Wook Han | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.identifier.doi | 10.1088/1748-6041/5/4/044109 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01169 | - |
dc.contributor.localId | A01482 | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A02426 | - |
dc.contributor.localId | A02777 | - |
dc.relation.journalcode | J00318 | - |
dc.identifier.eissn | 1748-605X | - |
dc.identifier.pmid | 20683126 | - |
dc.identifier.url | http://iopscience.iop.org/1748-605X/5/4/044109/ | - |
dc.contributor.alternativeName | Kim, Hye Lee | - |
dc.contributor.alternativeName | Park, Bong Joo | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Woo, Yeon I. | - |
dc.contributor.alternativeName | Lee, Mi Hee | - |
dc.contributor.affiliatedAuthor | Kim, Hye Lee | - |
dc.contributor.affiliatedAuthor | Park, Bong Joo | - |
dc.contributor.affiliatedAuthor | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | Woo, Yeon I. | - |
dc.contributor.affiliatedAuthor | Lee, Mi Hee | - |
dc.citation.volume | 5 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 044109 | - |
dc.identifier.bibliographicCitation | BIOMEDICAL MATERIALS, Vol.5(4) : 044109, 2010 | - |
dc.identifier.rimsid | 51620 | - |
dc.type.rims | ART | - |
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