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Correlation between quantitative serum HBsAg and HBV DNA test in Korean patients who showed high level of HBsAg.

 Jong-Han Lee  ;  Sue Jung Kim  ;  Sang Hoon Ahn  ;  Jinhwa Lee  ;  Yongjung Park  ;  Hyon-Suk Kim 
 JOURNAL OF CLINICAL PATHOLOGY, Vol.63(11) : 1027-1031, 2010 
Journal Title
Issue Date
Adult ; Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/virology ; DNA, Viral/blood* ; Female ; Hepatitis B Surface Antigens/blood* ; Hepatitis B e Antigens/blood ; Hepatitis B virus/genetics ; Hepatitis B virus/isolation & purification* ; Hepatitis B, Chronic/diagnosis* ; Hepatitis B, Chronic/drug therapy ; Humans ; Liver Cirrhosis/virology ; Liver Neoplasms/virology ; Male ; Middle Aged ; Retrospective Studies
Hepatitis B virus (HBV) ; quantitative hepatitis B surface antigen (HBsAg) ; HBV DNA ; correlation ; hepatitis ; laboratory tests
AIMS: The authors aimed to identify the correlation between quantitative hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA in Korean patients with a high level of HBsAg (>250 IU/ml) and characteristics of patients for whom quantitative HBsAg can be more suitably used to monitor HBV infection. METHODS: Quantitative HBsAg and HBV DNA were measured in collected sera from 565 patients with a high level of HBsAg (>250 IU/ml). The correlation between HBsAg and HBV DNA was analysed by Spearman rank test. We also retrospectively analysed the correlation according to the HBV infection phase in which quantitative HBsAg is more appropriate to be used in clinical practice. RESULTS: The overall correlation between quantitative HBsAg and HBV DNA was significant but very weak (Spearman ρ=0.121, p=0.004). Weak correlations were also noted in chronic hepatitis B patients (ρ=0.123, p=0.019) and in patients with hepatocellular carcinoma (ρ=0.328, p=0.002). No correlation was noted in liver cirrhosis patients (ρ=0.156, p=0.095). Relatively higher correlation was noted in hepatitis B e antigen positive patients without antiviral treatment and patients with a high HBV DNA to HBsAg ratio (>57.93). CONCLUSIONS: There was a weak correlation between quantitative HBsAg and HBV DNA. However, quantitative HBsAg appears to be more useful to reflect HBV DNA in the early replicative phase of chronic hepatitis B patients than those in the late non-replicative phase
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sue Jeong(김수정)
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Park, Yong Jung(박용정)
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Jong Han(이종한)
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