1 278

Cited 6 times in

Correlation between quantitative serum HBsAg and HBV DNA test in Korean patients who showed high level of HBsAg.

DC FieldValueLanguage
dc.contributor.author김수정-
dc.contributor.author김현숙-
dc.contributor.author박용정-
dc.contributor.author안상훈-
dc.contributor.author이종한-
dc.date.accessioned2015-04-23T17:21:06Z-
dc.date.available2015-04-23T17:21:06Z-
dc.date.issued2010-
dc.identifier.issn0021-9746-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102296-
dc.description.abstractAIMS: The authors aimed to identify the correlation between quantitative hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA in Korean patients with a high level of HBsAg (>250 IU/ml) and characteristics of patients for whom quantitative HBsAg can be more suitably used to monitor HBV infection. METHODS: Quantitative HBsAg and HBV DNA were measured in collected sera from 565 patients with a high level of HBsAg (>250 IU/ml). The correlation between HBsAg and HBV DNA was analysed by Spearman rank test. We also retrospectively analysed the correlation according to the HBV infection phase in which quantitative HBsAg is more appropriate to be used in clinical practice. RESULTS: The overall correlation between quantitative HBsAg and HBV DNA was significant but very weak (Spearman ρ=0.121, p=0.004). Weak correlations were also noted in chronic hepatitis B patients (ρ=0.123, p=0.019) and in patients with hepatocellular carcinoma (ρ=0.328, p=0.002). No correlation was noted in liver cirrhosis patients (ρ=0.156, p=0.095). Relatively higher correlation was noted in hepatitis B e antigen positive patients without antiviral treatment and patients with a high HBV DNA to HBsAg ratio (>57.93). CONCLUSIONS: There was a weak correlation between quantitative HBsAg and HBV DNA. However, quantitative HBsAg appears to be more useful to reflect HBV DNA in the early replicative phase of chronic hepatitis B patients than those in the late non-replicative phase-
dc.description.statementOfResponsibilityopen-
dc.format.extent1027~1031-
dc.relation.isPartOfJOURNAL OF CLINICAL PATHOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAntiviral Agents/therapeutic use-
dc.subject.MESHCarcinoma, Hepatocellular/virology-
dc.subject.MESHDNA, Viral/blood*-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B Surface Antigens/blood*-
dc.subject.MESHHepatitis B e Antigens/blood-
dc.subject.MESHHepatitis B virus/genetics-
dc.subject.MESHHepatitis B virus/isolation & purification*-
dc.subject.MESHHepatitis B, Chronic/diagnosis*-
dc.subject.MESHHepatitis B, Chronic/drug therapy-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis/virology-
dc.subject.MESHLiver Neoplasms/virology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.titleCorrelation between quantitative serum HBsAg and HBV DNA test in Korean patients who showed high level of HBsAg.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJong-Han Lee-
dc.contributor.googleauthorSue Jung Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorJinhwa Lee-
dc.contributor.googleauthorYongjung Park-
dc.contributor.googleauthorHyon-Suk Kim-
dc.identifier.doi10.1136/jcp.2010.078832-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00634-
dc.contributor.localIdA01582-
dc.contributor.localIdA02226-
dc.contributor.localIdA03151-
dc.contributor.localIdA01117-
dc.relation.journalcodeJ01334-
dc.identifier.eissn1472-4146-
dc.identifier.pmid20870658-
dc.identifier.urlhttp://jcp.bmj.com/content/63/11/1027-
dc.subject.keywordHepatitis B virus (HBV)-
dc.subject.keywordquantitative hepatitis B surface antigen (HBsAg)-
dc.subject.keywordHBV DNA-
dc.subject.keywordcorrelation-
dc.subject.keywordhepatitis-
dc.subject.keywordlaboratory tests-
dc.contributor.alternativeNameKim, Sue Jeong-
dc.contributor.alternativeNameKim, Hyon Suk-
dc.contributor.alternativeNamePark, Yong Jung-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Jong Han-
dc.contributor.affiliatedAuthorKim, Sue Jeong-
dc.contributor.affiliatedAuthorPark, Yong Jung-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Jong Han-
dc.contributor.affiliatedAuthorKim, Hyon Suk-
dc.citation.volume63-
dc.citation.number11-
dc.citation.startPage1027-
dc.citation.endPage1031-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL PATHOLOGY, Vol.63(11) : 1027-1031, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.