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Efficacy and feasibility of radiofrequency ablation for liver metastases from gastric adenocarcinoma

Authors
 Hye Ryun Kim  ;  Seong Ha Cheon  ;  Sun Young Rha  ;  Sung Hoon Noh  ;  Hyun Cheol Chung  ;  Sung Sook Lee  ;  Hei-Cheul Jeung  ;  Jung Ryun Ahn  ;  Kwang-Hun Lee 
Citation
 INTERNATIONAL JOURNAL OF HYPERTHERMIA, Vol.26(4) : 305-315, 2010 
Journal Title
 INTERNATIONAL JOURNAL OF HYPERTHERMIA 
ISSN
 0265-6736 
Issue Date
2010
MeSH
Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Adenocarcinoma/secondary ; Adenocarcinoma/surgery* ; Adult ; Aged ; Catheter Ablation/adverse effects ; Catheter Ablation/methods* ; Catheter Ablation/mortality ; Disease-Free Survival ; Feasibility Studies ; Female ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery* ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Retrospective Studies ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/surgery ; Treatment Outcome
Keywords
radiofrequency ablation ; gastric cancer ; liver metastases
Abstract
PURPOSE: Optimal treatment for liver metastases from gastric cancer remains a matter of debate. The aim of our study is to evaluate the efficacy of radiofrequency ablation (RFA) for the treatment of liver-only metastases from gastric adenocarcinoma. MATERIALS AND METHODS: We retrospectively reviewed medical records of 29 patients who developed liver-only metastases from gastric adenocarcinoma and subsequently underwent gastric resection and RFA (n = 20) or gastric resection and systemic chemotherapy (n = 9) between January 1995 and February 2008. Overall survival was estimated using the Kaplan-Meier method, and was compared using the log rank test to evaluate RFA efficacy. RESULTS: Twenty patients who underwent RFA showed a median overall survival of 30.7 months (range: 2.9 to 90.9 months), a median progression-free survival of 6.8 months (range: 0.8 to 45.2 months), and median overall one-, three-, and five-year survival rates were 66.8%, 40.1%, and 16.1% respectively. The RFA group showed a 76% decreased death rate compared to the chemotherapy-only group (30.7 months versus 7 months, hazard ratio, 0.24; p = 0.004). Most patients tolerated RFA well, and complications were found to be minor (transient fever (20%) and/or right upper quadrant pain (25%)). One case of treatment-related death occurred due to sepsis that originated from a liver abscess at the ablation site. CONCLUSIONS: The data suggest that a use of RFA as a liver-directed treatment may provide greater survival benefit than chemotherapy and is an alternative option for the treatment of liver-only metastases from gastric cancer.
Full Text
http://informahealthcare.com/doi/abs/10.3109/02656730903555696
DOI
10.3109/02656730903555696
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Ryun(김혜련) ORCID logo https://orcid.org/0000-0002-1842-9070
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Ahn, Jung Ryun(안정련)
Lee, Kwang Hoon(이광훈)
Lee, Sung Sook(이성숙)
Cheon, Seong Ha(전성하)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101974
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