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Screening for latent tuberculosis infection in South Korean healthcare workers using a tuberculin skin test and whole blood interferon-gamma assay

Authors
 Kyung Jong Lee  ;  Young Ae Kang  ;  Young Mi Kim  ;  Sang-Nae Cho  ;  Jin Wook Moon  ;  Moo Suk Park  ;  Se Kyu Kim  ;  Joon Chang  ;  Young Sam Kim 
Citation
 Scandinavian Journal of Infectious Diseases, Vol.42(9) : 672-678, 2010 
Journal Title
 Scandinavian Journal of Infectious Diseases 
ISSN
 0036-5548 
Issue Date
2010
Abstract
This study compared the results of a tuberculin skin test (TST) and a whole-blood interferon-gamma release assay (IGRA) to screen latent tuberculosis (TB) infection (LTBI) according to risk of TB exposure in South Korea. A cross-sectional comparison of 82 healthcare workers (HCWs) was performed from June 2009 to January 2010. Participants were grouped according to their risk for TB exposure: group 1, frequent and direct contact with active TB patients (n = 35); group 2, no known history of direct contact with active TB patients (n = 47). For the TST (10-mm induration cut-off), the positive response rate was 42.9% in group 1 and 34.0% in group 2 (p = 0.42). For the IGRA, the positive response rate was 40% in group 1 and 10.6% in group 2 (p = 0.002). Results obtained from the TST and the IGRA were not in significant agreement. The working duration of HCWs in TB-related departments was the only significant risk factor for LTBI (odds ratio 1.03; p = 0.031). Further, the IGRA can more accurately discriminate LTBI compared to the TST, based on the risk of TB exposure. These results suggest that the IGRA is diagnostically useful for LTBI in South Korean HCWs.
Full Text
http://informahealthcare.com/doi/abs/10.3109/00365548.2010.485575
DOI
10.3109/00365548.2010.485575
Appears in Collections:
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Se Kyu(김세규)
Kim, Young Mi(김영미)
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Moon, Jin Wook(문진욱)
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Lee, Kyung Jong(이경종)
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Cho, Sang Nae(조상래)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101955
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