1 974

Cited 38 times in

The role of ultrasonography and FDG-PET in axillary lymph node staging of breast cancer

 Jhii-Hyun Ahn  ;  Eun Ju Son  ;  Jeong-Ah Kim  ;  Ji Hyun Youk  ;  Eun-Kyung Kim  ;  Jin Young Kwak  ;  Young Hoon Ryu  ;  Joon Jeong 
 ACTA RADIOLOGICA, Vol.51(8) : 859-865, 2010 
Journal Title
Issue Date
Adult ; Aged ; Axilla ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology* ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology* ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Staging/methods ; Positron-Emission Tomography/methods* ; Radiopharmaceuticals ; Sensitivity and Specificity ; Ultrasonography, Mammary/methods*
Staging ; metastasis
BACKGROUND: The presence of axillary lymph node metastasis is the most important prognostic factor and an essential part of staging and prognosis of breast cancer.

PURPOSE: To elucidate the usefulness and accuracy of ultrasonography (US), fluorodeoxyglucose positron emission tomography (FDG-PET) scan, and combined analysis for axillary lymph node staging in breast cancer.

MATERIAL AND METHODS: A total of 250 consecutive breast cancer patients who had undergone US, FDG-PET, and sentinel lymph node biopsy (SLNB) before surgery from January 2005 to December 2006 were included in the study. If an axillary lymph node had a length to width ratio or=3 mm or compression of the hilum on US, focal hot uptake (maximal standardized uptake value, SUVmax >or=2.0) in the ipsilateral axilla on FDG-PET, it was considered to be a metastatic lymph node. In combined analysis of US and FDG-PET, the interpretation was considered positive if at least two of any of the criteria were met. Each imaging finding was compared with a pathologic report regarding the presence of axillary lymph node metastasis, the number of metastatic lymph nodes, and the T stage of the breast mass.

RESULTS: Pathologically confirmed axillary lymph node metastasis was noted in 73 cases (29.2%). The mean number of metastatic lymph nodes in pathology was 3.1 +/- 3.2, and the size of breast cancer was 2.0 +/- 1.04 cm. In the detection of lymph node metastasis, the diagnostic accuracy of US was 78.8% and that of FDG-PET was 76.4%. On combined US and FDG-PET, accuracy was improved (91.6%). The number of metastatic lymph nodes on pathology was correlated with the positivity of US and FDG-PET (P < 0.01).

CONCLUSION: Combined evaluation of US and FDG-PET was a sensitive and accurate method for axillary lymph node staging in breast cancer
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Ahn, Jhii Hyun(안지현)
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.