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Spontaneous healing capacity of rabbit cranial defects of various sizes

Authors
 Joo-Yeon Sohn  ;  Jung-Chul Park  ;  Yoo-Jung Um  ;  Ui-Won Jung  ;  Chang-Sung Kim  ;  Kyoo-Sung Cho  ;  Seong-Ho Choi 
Citation
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.40(4) : 180-187, 2010 
Journal Title
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE 
ISSN
 2093-2278 
Issue Date
2010
Keywords
Experimental design ; Osseous defect ; Wound healing
Abstract
PURPOSE: This study evaluated the spontaneous healing capacity of surgically produced cranial defects in rabbits with different healing periods in order to determine the critical size defect (CSD) of the rabbit cranium. METHODS: Thirty-two New Zealand white rabbits were used in this study. Defects of three sizes (6, 8, and 11 mm) were created in each of 16 randomly selected rabbits, and 15-mm defects were created individually in another 16 rabbits. The defects were analyzed using radiography, histologic analysis, and histometric analysis after the animal was sacrificed at 2, 4, 8, or 12 weeks postoperatively. Four samples were analyzed for each size of defect and each healing period. RESULTS: The radiographic findings indicated that defect filling gradually increased over time and that smaller defects were covered with a greater amount of radiopaque substance. Bony islands were observed at 8 weeks at the center of the defect in both histologic sections and radiographs. Histometrical values show that it was impossible to determine the precise CSD of the rabbit cranium. However, the innate healing capacity that originates from the defect margin was found to be constant regardless of the defect size. CONCLUSIONS: The results obtained for the spontaneous healing capacity of rabbit cranial defects over time and the underlying factors may provide useful guidelines for the development of a rabbit cranial model for in vivo investigations of new bone materials
Files in This Item:
T201002776.pdf Download
DOI
10.5051/jpis.2010.40.4.180
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Park, Jung Chul(박정철)
Um, Yoo Jung(엄유정)
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101711
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