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Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting.

 E. M. Choi  ;  M. G. Lee  ;  S. H. Lee  ;  K. W. Choi  ;  S. H. Choi 
 ANAESTHESIA, Vol.65(10) : 996-1000, 2010 
Journal Title
Issue Date
ATP Binding Cassette Transporter, Sub-Family B ; ATP-Binding Cassette, Sub-Family B, Member 1/genetics* ; Adult ; Anesthesia, General/methods ; Antiemetics/therapeutic use* ; Cholecystectomy, Laparoscopic ; Female ; Genotype ; Humans ; Intraoperative Care/methods ; Male ; Middle Aged ; Ondansetron/therapeutic use* ; Polymorphism, Genetic* ; Postoperative Nausea and Vomiting/genetics ; Postoperative Nausea and Vomiting/prevention & control* ; Prognosis ; Treatment Outcome
We investigated whether the 2677G>T/A and 3435C>T polymorphisms of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) affect the efficacy of ondansetron to prevent postoperative nausea and vomiting. One hundred and ninety-eight patients undergoing general anaesthesia were enrolled. Thirty minutes before the end of surgery, 0.1 mg.kg⁻¹ ondansetron was administered intravenously. The incidence of postoperative nausea and vomiting was compared between genotypes in the 2677G>T/A and 3435C>T polymorphisms of ABCB1. The incidence of postoperative nausea and vomiting was lower in patients with the 2677TT genotype (TT vs Non-TT = 25.9% vs 53.0%, p = 0.01) and 3435TT genotype (CC + CT vs TT = 52.6% vs 21.7%, p = 0.01) during the first 2 h after surgery. There were no significant differences in the incidence of postoperative nausea and vomiting between the different genotype groupings during period between 2 and 24 h after surgery. In conclusion, ABCB1 genotypes may be a clinical predictor of responsiveness for ondansetron.
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1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
Lee, Sung Hee(이성희)
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0001-8442-4406
Choi, Eun Kyeong(최은경)
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