Cited 51 times in
Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting.
DC Field | Value | Language |
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dc.contributor.author | 이민구 | - |
dc.contributor.author | 이성희 | - |
dc.contributor.author | 최승호 | - |
dc.contributor.author | 최은경 | - |
dc.date.accessioned | 2015-04-23T17:01:29Z | - |
dc.date.available | 2015-04-23T17:01:29Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0003-2409 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101680 | - |
dc.description.abstract | We investigated whether the 2677G>T/A and 3435C>T polymorphisms of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) affect the efficacy of ondansetron to prevent postoperative nausea and vomiting. One hundred and ninety-eight patients undergoing general anaesthesia were enrolled. Thirty minutes before the end of surgery, 0.1 mg.kg⁻¹ ondansetron was administered intravenously. The incidence of postoperative nausea and vomiting was compared between genotypes in the 2677G>T/A and 3435C>T polymorphisms of ABCB1. The incidence of postoperative nausea and vomiting was lower in patients with the 2677TT genotype (TT vs Non-TT = 25.9% vs 53.0%, p = 0.01) and 3435TT genotype (CC + CT vs TT = 52.6% vs 21.7%, p = 0.01) during the first 2 h after surgery. There were no significant differences in the incidence of postoperative nausea and vomiting between the different genotype groupings during period between 2 and 24 h after surgery. In conclusion, ABCB1 genotypes may be a clinical predictor of responsiveness for ondansetron. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 996~1000 | - |
dc.relation.isPartOf | ANAESTHESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | ATP Binding Cassette Transporter, Sub-Family B | - |
dc.subject.MESH | ATP-Binding Cassette, Sub-Family B, Member 1/genetics* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anesthesia, General/methods | - |
dc.subject.MESH | Antiemetics/therapeutic use* | - |
dc.subject.MESH | Cholecystectomy, Laparoscopic | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intraoperative Care/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Ondansetron/therapeutic use* | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/genetics | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/prevention & control* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | E. M. Choi | - |
dc.contributor.googleauthor | M. G. Lee | - |
dc.contributor.googleauthor | S. H. Lee | - |
dc.contributor.googleauthor | K. W. Choi | - |
dc.contributor.googleauthor | S. H. Choi | - |
dc.identifier.doi | 10.1111/j.1365-2044.2010.06476.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02781 | - |
dc.contributor.localId | A02876 | - |
dc.contributor.localId | A04146 | - |
dc.contributor.localId | A04101 | - |
dc.relation.journalcode | J00128 | - |
dc.identifier.eissn | 1365-2044 | - |
dc.identifier.pmid | 20707787 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2010.06476.x/abstract | - |
dc.contributor.alternativeName | Lee, Min Goo | - |
dc.contributor.alternativeName | Lee, Sung Hee | - |
dc.contributor.alternativeName | Choi, Seung Ho | - |
dc.contributor.alternativeName | Choi, Eun Kyeong | - |
dc.contributor.affiliatedAuthor | Lee, Min Goo | - |
dc.contributor.affiliatedAuthor | Lee, Sung Hee | - |
dc.contributor.affiliatedAuthor | Choi, Eun Kyeong | - |
dc.contributor.affiliatedAuthor | Choi, Seung Ho | - |
dc.citation.volume | 65 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 996 | - |
dc.citation.endPage | 1000 | - |
dc.identifier.bibliographicCitation | ANAESTHESIA, Vol.65(10) : 996-1000, 2010 | - |
dc.identifier.rimsid | 46661 | - |
dc.type.rims | ART | - |
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