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Benign lesions after partial nephrectomy for presumed renal cell carcinoma in masses 4 cm or less: prevalence and predictors in Korean patients

 Hwang Gyun Jeon  ;  Seung Ryeol Lee  ;  Kwang Hyun Kim  ;  Young Taik Oh  ;  Nam Hoon Cho  ;  Koon Ho Rha  ;  Seung Choul Yang  ;  Woong Kyu Han 
 UROLOGY, Vol.76(3) : 574-579, 2010 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/epidemiology* ; Carcinoma, Renal Cell/pathology* ; Carcinoma, Renal Cell/surgery ; Female ; Humans ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/epidemiology* ; Kidney Neoplasms/pathology* ; Kidney Neoplasms/surgery ; Male ; Middle Aged ; Nephrectomy*/methods ; Predictive Value of Tests ; Prevalence ; Republic of Korea ; Retrospective Studies ; Young Adult
OBJECTIVES: To investigate the prevalence and predictors associated with benign lesions in Korean patients after partial nephrectomy for presumed renal cell carcinoma (RCC) for lesions measuring ≤ 4 cm.

METHODS: We retrospectively investigated the medical records of 376 patients who underwent partial nephrectomy for presumed RCC with renal masses of size ≤ 4 cm between June 1997 and December 2008. Demographic and clinicopathologic parameters were compared between benign lesions and RCC. Logistic regression was done to identify parameters associated with benign lesions.

RESULTS: In the 376 patients, 81 tumors (21.5%) were benign, including 35 angiomyolipomas (9.3%), 26 complicated cysts (6.9%), 11 oncocytomas (2.9%), and 9 others (2.4%). Univariate analysis showed that time of surgery, female sex, younger age, and normal body mass index (body mass index (BMI) < 23 kg/m(2)) were associated with benign pathologic findings. On multiple logistic regression analysis, female sex (OR, 4.91; 95% CI, 2.76-08.75; P < .001), age (OR, 0.97; 95% CI, 0.95-0.99; P = .009), and time of surgery (OR, 0.33; 95% CI, 0.11-0.95; P = .040) were independent predictors of benign histologic features. Tumor size, incidental diagnosis, and BMI were not significant predictors (P > .05).

CONCLUSIONS: Our study with a large cohort of Asian patients showed that the prevalence of benign lesions was similar to previously reported Western studies. However, the most common benign lesion was angiomyolipoma, compared with oncocytoma in Western countries. The results of this study may help clinicians counsel female and younger patients recently diagnosed with small renal masses and decide the most appropriate treatment, including renal biopsies and close observation.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Yang, Seung Choul(양승철)
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
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