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High peritoneal transport status is not an independent risk factor for high mortality in patients treated with automated peritoneal dialysis

 Tae Ik Chang  ;  Jung Tak Park  ;  Dong Hyung Lee  ;  Ju Hyun Lee  ;  Tae Hyun Yoo  ;  Beom Seok Kim  ;  Shin-Wook Kang  ;  Ho Yung Lee  ;  Kyu Hun Choi 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.25(9) : 1313-1317, 2010 
Journal Title
Issue Date
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Automation ; Cardiovascular Diseases/complications ; Diabetes Complications ; Dialysis Solutions/therapeutic use ; Female ; Glomerular Filtration Rate ; Glucans/therapeutic use ; Glucose/therapeutic use ; Humans ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Multivariate Analysis ; Peritoneal Dialysis/mortality* ; Retrospective Studies ; Risk Factors ; Serum Albumin/analysis ; Survival Rate
Automated Peritoneal Dialysis ; High Transport ; Mortality ; Peritoneal Equilibration Test
We undertook this study to elucidate whether baseline peritoneal membrane transport characteristics are associated with high mortality in incident automated peritoneal dialysis (APD) patients. This retrospective study includes 117 patients who started APD at Yonsei University Health System from 1996 to 2008 and had a PET within 3 months of APD initiation. High transporters were significantly older and had a higher incidence of cardiovascular disease. Patient survival for years 1, 3, and 5 were 85%, 64%, and 35% for high transporter and 94%, 81%, and 68% for non-high transporter group (P<0.01). Multivariate analysis revealed that age, diabetes, cardiovascular disease, serum albumin level, and residual renal function were independently associated with high mortality in APD patients. In contrast, high transport status was not a significant predictor for mortality in this population when the other covariates were included. Even though high transport was significantly associated with mortality in the univariate analysis, its role seemed to be influenced by other comorbid conditions. These findings suggest that the proper management of these comorbid conditions, as well as appropriate ultrafiltration by use of APD and/or icodextrin, must be considered as protective strategies to improve survival in peritoneal dialysis patients with high transport.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Rah, Dong Kyun(나동균)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Dong Hyoung(이동형)
Lee, Joo Hyun(이주현)
Lee, Ho Yung(이호영)
Chang, Tae Ik(장태익)
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
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