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A case of nephrotic syndrome in a patient with Churg-Strauss syndrome

 Sun Young Park  ;  Jae Hyun Chang  ;  Hyun-Wook Kim  ;  Dong Ki Kim  ;  Eun Young Kim  ;  Jung Tak Park  ;  Tae Ik Chang  ;  Jung Won Park  ;  Hyeon Joo Jeong  ;  Dae-Suk Han  ;  Shin-Wook Kang 
 RHEUMATOLOGY INTERNATIONAL, Vol.30(10) : 1385-1388, 2010 
Journal Title
Issue Date
Adult ; Churg-Strauss Syndrome/complications* ; Churg-Strauss Syndrome/drug therapy ; Churg-Strauss Syndrome/pathology ; Cyclophosphamide/therapeutic use ; Drug Therapy, Combination ; Female ; Glomerular Mesangium/ultrastructure ; Glomerulosclerosis, Focal Segmental/complications ; Glomerulosclerosis, Focal Segmental/drug therapy ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Immunosuppressive Agents/therapeutic use ; Nephrotic Syndrome/complications* ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/pathology ; Prednisolone/therapeutic use ; Proteinuria/complications ; Proteinuria/drug therapy ; Proteinuria/pathology ; Pulse Therapy, Drug ; Treatment Outcome
Nephrotic syndrome ; Focal segmental glomerulosclerosis ; Churg–Strauss syndrome
Renal involvement in Churg-Strauss syndrome (CSS) is not uncommon, but nephrotic syndrome is rarely reported in patients with CSS. A 25-year-old woman with a long history of bronchial asthma presented to our hospital with a chief complaint of generalized edema. Laboratory studies revealed normocytic normochromic anemia, marked eosinophilia, positive anti-neutrophil cytoplasmic antibody, hypoalbuminemia, and hypercholesterolemia. Urinalysis showed heavy proteinuria (4+) without significant casts. The 24-hour urinary protein excretion was 6.5 g with a selective index of 0.35. Echocardiography and X-ray of the paranasal sinuses suggested restrictive cardiomyopathy and maxillary sinusitis, respectively. Diagnoses of CSS and nephrotic syndrome were made on the basis of clinical and laboratory findings. Renal biopsy was performed, and pathologic findings revealed focal segmental glomerulosclerosis with mesangiolysis. The patient's clinical symptoms and proteinuria improved markedly after combined treatment with corticosteroids and cyclophosphamide. Herein, we report a case of nephrotic syndrome in a patient with CSS.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Dong Ki(김동기)
Kim, Dong Ik(김동익)
Kim, Hyun Wook(김현욱) ORCID logo https://orcid.org/0000-0002-4274-7562
Park, Sun Young(박선영)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
Han, Dae Suk(한대석)
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