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Restoration of mammillothalamic functional connectivity through thiamine replacement therapy in Wernicke's encephalopathy

 Eosu Kim  ;  Jeonghun Ku  ;  Young-Chul Jung  ;  Hyeongrae Lee  ;  Sun I. Kim  ;  Jae-Jin Kim  ;  Kee Namkoong  ;  Dong-Ho Song 
 Neuroscience Letters, Vol.479(3) : 257-261, 2010 
Journal Title
 Neuroscience Letters 
Issue Date
Resting-state functional MRI (fMRI) is now providing further understanding of neuropsychiatric illnesses. However, its practical applicability in the clinical realms is still questionable. Here we report three consecutive followed-up resting-state fMRI data in a single case with Wernicke encephalopathy before and after high-dose thiamine replacement therapy ranging over 20 months. We measured the mammillothalamic functional connectivity strength between the first ROI (mammillary body) and a voxel which showed the highest co-activation among voxels within the anterior thalamus (the second ROI) to enhance the specificity of the functional connectivity data. We found that the time-series changes in the mammillothalamic functional connectivity generally paralleled to the changes in delayed verbal and nonverbal recall memory scores in the left and right hemisphere, respectively. Among these, the left-side connectivity and delayed verbal recall score seemed to be related to the overall clinical status change. Modified directed transfer function (dDTF) analysis also identified significant information flows with mammillary-to-thalamic direction except at the acute illness state. Our findings, though preliminary in nature, suggest the practical applicability of resting-state fMRI to trace an effect of thiamine replacement therapy on the memory tract function in Wernicke encephalopathy at single-patient level
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
김어수(Kim, Eosu) ORCID logo https://orcid.org/0000-0001-9472-9465
김재진(Kim, Jae Jin) ORCID logo https://orcid.org/0000-0002-1395-4562
남궁기(Namkoong, Kee) ORCID logo https://orcid.org/0000-0003-1400-8057
송동호(Song, Dong Ho) ORCID logo https://orcid.org/0000-0002-9647-3130
정영철(Jung, Young Chul) ORCID logo https://orcid.org/0000-0002-0578-2510
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