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Restoration of mammillothalamic functional connectivity through thiamine replacement therapy in Wernicke's encephalopathy

DC FieldValueLanguage
dc.contributor.author김어수-
dc.contributor.author김재진-
dc.contributor.author남궁기-
dc.contributor.author송동호-
dc.contributor.author정영철-
dc.date.accessioned2015-04-23T16:47:40Z-
dc.date.available2015-04-23T16:47:40Z-
dc.date.issued2010-
dc.identifier.issn0304-3940-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101238-
dc.description.abstractResting-state functional MRI (fMRI) is now providing further understanding of neuropsychiatric illnesses. However, its practical applicability in the clinical realms is still questionable. Here we report three consecutive followed-up resting-state fMRI data in a single case with Wernicke encephalopathy before and after high-dose thiamine replacement therapy ranging over 20 months. We measured the mammillothalamic functional connectivity strength between the first ROI (mammillary body) and a voxel which showed the highest co-activation among voxels within the anterior thalamus (the second ROI) to enhance the specificity of the functional connectivity data. We found that the time-series changes in the mammillothalamic functional connectivity generally paralleled to the changes in delayed verbal and nonverbal recall memory scores in the left and right hemisphere, respectively. Among these, the left-side connectivity and delayed verbal recall score seemed to be related to the overall clinical status change. Modified directed transfer function (dDTF) analysis also identified significant information flows with mammillary-to-thalamic direction except at the acute illness state. Our findings, though preliminary in nature, suggest the practical applicability of resting-state fMRI to trace an effect of thiamine replacement therapy on the memory tract function in Wernicke encephalopathy at single-patient level-
dc.description.statementOfResponsibilityopen-
dc.format.extent257~261-
dc.relation.isPartOfNeuroscience Letters-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRestoration of mammillothalamic functional connectivity through thiamine replacement therapy in Wernicke's encephalopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorEosu Kim-
dc.contributor.googleauthorJeonghun Ku-
dc.contributor.googleauthorYoung-Chul Jung-
dc.contributor.googleauthorHyeongrae Lee-
dc.contributor.googleauthorSun I. Kim-
dc.contributor.googleauthorJae-Jin Kim-
dc.contributor.googleauthorKee Namkoong-
dc.contributor.googleauthorDong-Ho Song-
dc.identifier.doi10.1016/j.neulet.2010.05.074-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03656-
dc.contributor.localIdA00686-
dc.contributor.localIdA00870-
dc.contributor.localIdA01240-
dc.contributor.localIdA02018-
dc.relation.journalcodeJ02364-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304394010006919-
dc.contributor.alternativeNameKim, Eo Su-
dc.contributor.alternativeNameKim, Jae Jin-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.alternativeNameSong, Dong Ho-
dc.contributor.alternativeNameJung, Young Chul-
dc.contributor.affiliatedAuthorJung, Young Chul-
dc.contributor.affiliatedAuthorKim, Eo Su-
dc.contributor.affiliatedAuthorKim, Jae Jin-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.contributor.affiliatedAuthorSong, Dong Ho-
dc.citation.volume479-
dc.citation.number3-
dc.citation.startPage257-
dc.citation.endPage261-
dc.identifier.bibliographicCitationNeuroscience Letters, Vol.479(3) : 257-261, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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