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Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China

Authors
 Bum Sik Chin  ;  Jun Yong Choi  ;  Yang Han  ;  Jiqiu Kuang  ;  Yanling Li  ;  Sang Hoon Han  ;  Heekyoung Choi  ;  Yun Tae Chae  ;  Sung Joon Jin  ;  Ji-Hyeon Baek  ;  Young-Soun Lim  ;  Chang Oh Kim  ;  Young Goo Song  ;  Dongeun Yong  ;  TaiSheng Li  ;  June Myung Kim 
Citation
 AIDS Research and Human Retroviruses, Vol.26(2) : 217-221, 2010 
Journal Title
 AIDS Research and Human Retroviruses 
ISSN
 0889-2229 
Issue Date
2010
MeSH
Adult ; China ; Cluster Analysis ; Drug Resistance, Viral* ; Female ; Geography ; HIV Infections/virology* ; HIV-1/drug effects* ; HIV-1/genetics* ; HIV-1/isolation & purification ; Humans ; Korea ; Male ; Molecular Epidemiology ; Molecular Sequence Data ; Mutation, Missense* ; Phylogeny ; Polymorphism, Genetic ; Sequence Analysis, DNA ; Viral Proteins/genetics* ; Young Adult
Abstract
Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p < 0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.
Full Text
http://online.liebertpub.com/doi/abs/10.1089/aid.2009.0157
DOI
10.1089/aid.2009.0157
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Baek, Ji Hyeon(백지현)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Im, Young Sun(임영선)
Chin, Bum Sik(진범식)
Jin, Sung Joon(진성준)
Chae, Yun Tae(채윤태)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101158
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