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Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China

Authors
 Bum Sik Chin  ;  Jun Yong Choi  ;  Yang Han  ;  Jiqiu Kuang  ;  Yanling Li  ;  Sang Hoon Han  ;  Heekyoung Choi  ;  Yun Tae Chae  ;  Sung Joon Jin  ;  Ji-Hyeon Baek  ;  Young-Soun Lim  ;  Chang Oh Kim  ;  Young Goo Song  ;  Dongeun Yong  ;  TaiSheng Li  ;  June Myung Kim 
Citation
 AIDS Research and Human Retroviruses, Vol.26(2) : 217-221, 2010 
Journal Title
 AIDS Research and Human Retroviruses 
ISSN
 0889-2229 
Issue Date
2010
Abstract
Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p < 0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.
Full Text
http://online.liebertpub.com/doi/abs/10.1089/aid.2009.0157
DOI
10.1089/aid.2009.0157
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
김준명(Kim, June Myung)
백지현(Baek, Ji Hyeon)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
임영선(Im, Young Sun)
진범식(Chin, Bum Sik)
진성준(Jin, Sung Joon)
채윤태(Chae, Yun Tae)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
최희경(Choi, Hee Kyoung)
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101158
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