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Correlates of the severity of coronary atherosclerosis in long-term kidney transplant patients

Authors
 Hyun-Wook Kim  ;  Shin-Wook Kang  ;  Ho Yung Lee  ;  Dong-Hoon Choi  ;  Won-Heum Shim  ;  Soon Il Kim  ;  Yu Seun Kim  ;  Kyu Hun Choi 
Citation
 Journal of Korean Medical Science, Vol.25(5) : 706-711, 2010 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2010
Abstract
Coronary artery disease remains the leading cause of early death and graft loss in renal transplant patients. The aim of this study was to identify clinical and echocardiographic parameters independently associated with the angiographically-determined severity of coronary atherosclerosis in long-term kidney transplant patients. Fifty-two kidney transplant recipients who underwent elective coronary angiography were reviewed retrospectively. Angiographic severity was evaluated using the modified Gensini index (MGI). The mean age at coronary angiography was 52.5+/-7.9 yr with a mean prior transplant duration of 118.1+/-58.8 months. Pearson correlation analysis demonstrated a positive correlation of MGI with transplant duration before coronary angiography and chronic allograft nephropathy, whereas an inverse correlation was demonstrated with ejection fraction and statin use. On subsequent multivariate linear regression analysis, transplant duration before coronary angiography, statin use, and ejection fraction were independently associated with the severity of coronary atherosclerosis in long-term kidney transplant patients. In summary, our study demonstrates that statin use, ejection fraction, and transplant duration before coronary angiography are independent parameters associated with the severity of coronary atherosclerosis in long-term kidney transplant patients. Further investigation is required to reduce the atherosclerotic burden in kidney transplant patients
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DOI
10.3346/jkms.2010.25.5.706
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강신욱(Kang, Shin Wook) ORCID logo https://orcid.org/0000-0002-5677-4756
김순일(Kim, Soon Il) ORCID logo https://orcid.org/0000-0002-0783-7538
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
김현욱(Kim, Hyun Wook) ORCID logo https://orcid.org/0000-0002-4274-7562
심원흠(Shim, Won Heum)
이호영(Lee, Ho Yung)
최규헌(Choi, Kyu Hun) ORCID logo https://orcid.org/0000-0003-0095-9011
최동훈(Choi, Dong Hoon) ORCID logo https://orcid.org/0000-0002-2009-9760
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101102
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