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Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine

Authors
 Yoon Suk Jung  ;  Jae Hee Cheon  ;  Jae Jun Park  ;  Chang Mo Moon  ;  Eun Soo Kim  ;  Jin Ha Lee  ;  Seung Won Kim  ;  Jae Hak Kim  ;  Sung Pil Hong  ;  Tae Il Kim  ;  Won Ho Kim 
Citation
 Journal of Human Genetics, Vol.55(2) : 121-123, 2010 
Journal Title
 Journal of Human Genetics 
ISSN
 1434-5161 
Issue Date
2010
Abstract
There is a lack of research describing the associations between thiopurine methyltransferase (TPMT)/inosine triphosphate pyrophosphatase (ITPA) genotypes and long-term clinical outcomes. We investigated whether TPMT/ITPA genotypes predicted long-term clinical response in Korean patients with inflammatory bowel diseases (IBDs) undergoing thiopurine treatment. A total of 204 patients with IBD in whom thiopurine treatment was indicated were enrolled and categorized by TPMT and ITPA genotypes. Long-term follow-up clinical data for these patients were analyzed with specific focus on disease relapse. Of the 204 patients, 162 (79.4%) patients using thiopurines achieved remission and were included in an analysis of long-term clinical outcomes. There were no significant differences in disease relapse-free survival between wild and mutant types of TPMT (P=0.903) or ITPA (P=0.392), according to the results of the log-rank analysis. Our study suggests that TPMT and ITPA genotypes may not affect the rates of disease relapse in IBD patients treated with thiopurines. Further studies are indicated to confirm the utility of TPMT/ITPA genotyping to guide clinicians formulating individualized treatments for IBD patients requiring thiopurine therapy
Full Text
http://www.nature.com/jhg/journal/v55/n2/full/jhg2009125a.html
DOI
10.1038/jhg.2009.125
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김승원(Kim, Seung Won)
김원호(Kim, Won Ho)
김은수(Kim, Eun Soo)
김태일(Kim, Tae Il) ORCID logo https://orcid.org/0000-0003-4807-890X
문창모(Moon, Chang Mo)
박재준(Park, Jae Jun)
이진하(Lee, Jin Ha)
정윤숙(Jung, Yoon Suk)
천재희(Cheon, Jae Hee) ORCID logo https://orcid.org/0000-0002-2282-8904
홍성필(Hong, Sung Pil)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101056
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