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Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine

DC FieldValueLanguage
dc.contributor.author김승원-
dc.contributor.author김원호-
dc.contributor.author김은수-
dc.contributor.author김태일-
dc.contributor.author문창모-
dc.contributor.author박재준-
dc.contributor.author이진하-
dc.contributor.author정윤숙-
dc.contributor.author천재희-
dc.contributor.author홍성필-
dc.date.accessioned2015-04-23T16:41:53Z-
dc.date.available2015-04-23T16:41:53Z-
dc.date.issued2010-
dc.identifier.issn1434-5161-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101056-
dc.description.abstractThere is a lack of research describing the associations between thiopurine methyltransferase (TPMT)/inosine triphosphate pyrophosphatase (ITPA) genotypes and long-term clinical outcomes. We investigated whether TPMT/ITPA genotypes predicted long-term clinical response in Korean patients with inflammatory bowel diseases (IBDs) undergoing thiopurine treatment. A total of 204 patients with IBD in whom thiopurine treatment was indicated were enrolled and categorized by TPMT and ITPA genotypes. Long-term follow-up clinical data for these patients were analyzed with specific focus on disease relapse. Of the 204 patients, 162 (79.4%) patients using thiopurines achieved remission and were included in an analysis of long-term clinical outcomes. There were no significant differences in disease relapse-free survival between wild and mutant types of TPMT (P=0.903) or ITPA (P=0.392), according to the results of the log-rank analysis. Our study suggests that TPMT and ITPA genotypes may not affect the rates of disease relapse in IBD patients treated with thiopurines. Further studies are indicated to confirm the utility of TPMT/ITPA genotyping to guide clinicians formulating individualized treatments for IBD patients requiring thiopurine therapy-
dc.description.statementOfResponsibilityopen-
dc.format.extent121~123-
dc.relation.isPartOfJournal of Human Genetics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCorrelation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorYoon Suk Jung-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorChang Mo Moon-
dc.contributor.googleauthorEun Soo Kim-
dc.contributor.googleauthorJin Ha Lee-
dc.contributor.googleauthorSeung Won Kim-
dc.contributor.googleauthorJae Hak Kim-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.identifier.doi10.1038/jhg.2009.125-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA01390-
dc.contributor.localIdA01636-
dc.contributor.localIdA03231-
dc.contributor.localIdA03680-
dc.contributor.localIdA04404-
dc.contributor.localIdA00804-
dc.contributor.localIdA00656-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ01446-
dc.identifier.urlhttp://www.nature.com/jhg/journal/v55/n2/full/jhg2009125a.html-
dc.contributor.alternativeNameKim, Seung Won-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Eun Soo-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNameMoon, Chang Mo-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNameLee, Jin Ha-
dc.contributor.alternativeNameJung, Yoon Suk-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorMoon, Chang Mo-
dc.contributor.affiliatedAuthorPark, Jae Jun-
dc.contributor.affiliatedAuthorLee, Jin Ha-
dc.contributor.affiliatedAuthorJung, Yoon Suk-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Eun Soo-
dc.contributor.affiliatedAuthorKim, Seung Won-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.citation.volume55-
dc.citation.number2-
dc.citation.startPage121-
dc.citation.endPage123-
dc.identifier.bibliographicCitationJournal of Human Genetics, Vol.55(2) : 121-123, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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