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The effects of newly formed synthetic peptide on bone regeneration in rat calvarial defects

Authors
 Jung-Yoo Choi  ;  Ui-Won Jung  ;  Chang-Sung Kim  ;  Tae-Kwan Eom  ;  Eun-Jung Kang  ;  Kyoo-Sung Cho  ;  Chong-Kwan Kim  ;  Seong-Ho Choi 
Citation
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.40(1) : 11-18, 2010 
Journal Title
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE 
ISSN
 2093-2278 
Issue Date
2010
Keywords
Bone regeneration ; Collagen ; Synthetic peptide
Abstract
PURPOSE: Significant interest has emerged in the design of cell scaffolds that incorporate peptide sequences that correspond to known signaling domains in extracellular matrix and bone morphogenetic protein. The purpose of this study was to evaluate the bone regenerative effects of the synthetic peptide in a critical-size rat calvarial defect model. METHODS: Eight millimeter diameter standardized, circular, transosseus defects created on the cranium of forty rats were implanted with synthetic peptide, collagen, or both synthetic peptide and collagen. No material was was implanted the control group. The healing of each group was evaluated histologically and histomorphometrically after 2- and 8-week healing intervals. RESULTS: Surgical implantation of the synthetic peptide and collagen resulted in enhanced local bone formation at both 2 and 8 weeks compared to the control group. When the experimental groups were compared to each other, they showed a similar pattern of bone formation. The defect closure and new bone area were significantly different in synthetic peptide and collagen group at 8 weeks. CONCLUSIONS: Concerning the advantages of biomaterials, synthetic peptide can be an effective biomaterial for damaged periodontal regeneration
Files in This Item:
T201001146.pdf Download
DOI
10.5051/jpis.2010.40.1.11
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100995
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