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Focal eosinophilic necrosis on superparamagnetic iron oxide-enhanced MRI

 Eun-Suk Cho  ;  Jeong-Sik Yu  ;  Myeong-Jin Kim  ;  Joo Hee Kim  ;  Jae-Joon Chung  ;  Ki Whang Kim 
 AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.194(5) : 1296-1302, 2010 
Journal Title
Issue Date
Adult ; Aged ; Contrast Media ; Diagnosis, Differential ; Eosinophilia/diagnosis* ; Female ; Ferrosoferric Oxide* ; Hepatic Encephalopathy/diagnosis* ; Humans ; Image Enhancement/methods* ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/secondary* ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Necrosis/diagnosis ; Reproducibility of Results ; Sensitivity and Specificity
eosinophil ; liver ; MRI ; superparamagnetic iron oxide (SPIO)
OBJECTIVE: The purpose of our study was to evaluate the usefulness of superparamagnetic iron oxide (SPIO)-enhanced MRI for distinguishing focal eosinophilic necrosis (FEN) from hepatic metastasis.

MATERIALS AND METHODS: Forty-one cases of FEN in 41 patients and 40 hepatic metastases in 40 patients were analyzed on unenhanced and SPIO-enhanced T2-weighted MRI retrospectively. Depending on the extent of the remaining hyperintense area on SPIO-enhanced T2-weighted images compared with the unenhanced images, the lesions were classified into four categories--category 1, less than 25%; category 2, 25-49%; category 3, 50-75%; and category 4, more than 75%--by two independent readers. Contrast-to-noise ratio (CNR) was measured using the same region of interest on unenhanced and SPIO-enhanced T2-weighted images. In three pathologic specimens of FEN, the number of Kupffer cells was compared with that of background hepatic parenchyma.

RESULTS: All metastases were classified as category 4, whereas FEN showed various distributions overall (category 1, 45.2%; category 2, 24.6%; category 3, 13.4%; category 4, 17.1%). FEN showed a decrease in CNR (from 7.9 +/- 5.8 to 6.1 +/- 5.6, p < 0.05), and metastases showed an increase in CNR (from 33.7 +/- 27.0 to 55.0 +/- 44.3, p < 0.05) after SPIO administration. In biopsy specimens, FEN had many more Kupffer cells (174.7 +/- 120.3 cells/high-power field [hpf]) than background hepatic parenchyma (23.7 +/- 9.8 cells/hpf). When using signal loss categories 1, 2, or 3 or CNR decrease, the accuracy of SPIO enhancement was 88.3%.

CONCLUSION: Unlike hepatic metastases, most of the cases of FEN showed a reduction in the extent of hyperintense area or a decrease in CNR after SPIO administration on the T2-weighted images. Therefore, SPIO-enhanced T2-weighted MRI can help to differentially diagnose FEN from metastases.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
Cho, Eun Suk(조은석)
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