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Focal eosinophilic necrosis on superparamagnetic iron oxide-enhanced MRI

DC Field Value Language
dc.contributor.author유정식-
dc.contributor.author정재준-
dc.contributor.author조은석-
dc.contributor.author김기황-
dc.contributor.author김명진-
dc.contributor.author김주희-
dc.date.accessioned2015-04-23T16:36:51Z-
dc.date.available2015-04-23T16:36:51Z-
dc.date.issued2010-
dc.identifier.issn0361-803X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100903-
dc.description.abstractOBJECTIVE: The purpose of our study was to evaluate the usefulness of superparamagnetic iron oxide (SPIO)-enhanced MRI for distinguishing focal eosinophilic necrosis (FEN) from hepatic metastasis. MATERIALS AND METHODS: Forty-one cases of FEN in 41 patients and 40 hepatic metastases in 40 patients were analyzed on unenhanced and SPIO-enhanced T2-weighted MRI retrospectively. Depending on the extent of the remaining hyperintense area on SPIO-enhanced T2-weighted images compared with the unenhanced images, the lesions were classified into four categories--category 1, less than 25%; category 2, 25-49%; category 3, 50-75%; and category 4, more than 75%--by two independent readers. Contrast-to-noise ratio (CNR) was measured using the same region of interest on unenhanced and SPIO-enhanced T2-weighted images. In three pathologic specimens of FEN, the number of Kupffer cells was compared with that of background hepatic parenchyma. RESULTS: All metastases were classified as category 4, whereas FEN showed various distributions overall (category 1, 45.2%; category 2, 24.6%; category 3, 13.4%; category 4, 17.1%). FEN showed a decrease in CNR (from 7.9 +/- 5.8 to 6.1 +/- 5.6, p < 0.05), and metastases showed an increase in CNR (from 33.7 +/- 27.0 to 55.0 +/- 44.3, p < 0.05) after SPIO administration. In biopsy specimens, FEN had many more Kupffer cells (174.7 +/- 120.3 cells/high-power field [hpf]) than background hepatic parenchyma (23.7 +/- 9.8 cells/hpf). When using signal loss categories 1, 2, or 3 or CNR decrease, the accuracy of SPIO enhancement was 88.3%. CONCLUSION: Unlike hepatic metastases, most of the cases of FEN showed a reduction in the extent of hyperintense area or a decrease in CNR after SPIO administration on the T2-weighted images. Therefore, SPIO-enhanced T2-weighted MRI can help to differentially diagnose FEN from metastases.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1296~1302-
dc.relation.isPartOfAMERICAN JOURNAL OF ROENTGENOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHContrast Media-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHEosinophilia/diagnosis*-
dc.subject.MESHFemale-
dc.subject.MESHFerrosoferric Oxide*-
dc.subject.MESHHepatic Encephalopathy/diagnosis*-
dc.subject.MESHHumans-
dc.subject.MESHImage Enhancement/methods*-
dc.subject.MESHLiver Neoplasms/diagnosis*-
dc.subject.MESHLiver Neoplasms/secondary*-
dc.subject.MESHMagnetic Resonance Imaging/methods*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNecrosis/diagnosis-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSensitivity and Specificity-
dc.titleFocal eosinophilic necrosis on superparamagnetic iron oxide-enhanced MRI-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorEun-Suk Cho-
dc.contributor.googleauthorJeong-Sik Yu-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.contributor.googleauthorJoo Hee Kim-
dc.contributor.googleauthorJae-Joon Chung-
dc.contributor.googleauthorKi Whang Kim-
dc.identifier.doi10.2214/AJR.09.3208-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00951-
dc.contributor.localIdA02500-
dc.contributor.localIdA03712-
dc.contributor.localIdA03881-
dc.contributor.localIdA00345-
dc.contributor.localIdA00426-
dc.relation.journalcodeJ00116-
dc.identifier.eissn1546-3141-
dc.identifier.pmid20410417-
dc.identifier.urlhttp://www.ajronline.org/doi/abs/10.2214/AJR.09.3208-
dc.subject.keywordeosinophil-
dc.subject.keywordliver-
dc.subject.keywordMRI-
dc.subject.keywordsuperparamagnetic iron oxide (SPIO)-
dc.contributor.alternativeNameYu, Jeong Sik-
dc.contributor.alternativeNameChung, Jae Joon-
dc.contributor.alternativeNameCho, Eun Suk-
dc.contributor.alternativeNameKim, Ki Whang-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.alternativeNameKim, Joo Hee-
dc.contributor.affiliatedAuthorKim, Joo Hee-
dc.contributor.affiliatedAuthorYu, Jeong Sik-
dc.contributor.affiliatedAuthorChung, Jae Joon-
dc.contributor.affiliatedAuthorCho, Eun Suk-
dc.contributor.affiliatedAuthorKim, Ki Whang-
dc.contributor.affiliatedAuthorKim, Myeong Jin-
dc.citation.volume194-
dc.citation.number5-
dc.citation.startPage1296-
dc.citation.endPage1302-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF ROENTGENOLOGY, Vol.194(5) : 1296-1302, 2010-
dc.identifier.rimsid55634-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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