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Extranodal nasal-type NK/T-cell lymphoma: computed tomography findings of head and neck involvement

 Jinna Kim  ;  Eung Yeop Kim  ;  Seung-Koo Lee  ;  Dong Ik Kim  ;  Chang-Hoon Kim  ;  Se-Heon Kim  ;  Eun Chang Choi 
 ACTA RADIOLOGICA, Vol.51(2) : 164-169, 2010 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Contrast Media ; Female ; Head and Neck Neoplasms/diagnostic imaging* ; Head and Neck Neoplasms/pathology ; Humans ; Iohexol/analogs & derivatives ; Lymphoma, Extranodal NK-T-Cell/diagnostic imaging* ; Lymphoma, Extranodal NK-T-Cell/pathology ; Male ; Middle Aged ; Nose Neoplasms/diagnostic imaging* ; Nose Neoplasms/pathology ; Radiographic Image Interpretation, Computer-Assisted ; Retrospective Studies ; Tomography, X-Ray Computed/methods*
Computed tomography ; extranodal NK/T-cell lymphoma ; nasal cavity ; X-ray
BACKGROUND: Extranodal nasal-type natural killer (NK)/T-cell lymphoma (NKTL) is a rare, but distinct clinical entity in Asian populations. However, it is not uncommon for NKTL to be belatedly or postoperatively diagnosed because radiologists are not familiar with its radiological features.

PURPOSE: To investigate the computed tomography (CT) findings in patients with extranodal nasal-type NKTL involving the head and neck.

MATERIAL AND METHODS: Twenty-nine patients (18 male, 11 female; mean age 51.5 years) with pathologically proven extranodal nasal-type NKTL were enrolled in this study. Two head-and-neck radiologists retrospectively evaluated the CT scans with special attention to the primary site, the extent of involvement, and patterns of the lesions (i.e., morphologic features, ulceration or necrosis, and bone destruction).

RESULTS: The cases of nasal-type NKTL consisted of primary tumors arising from the sinonasal cavity in 13 patients (45%), the naso/oropharynx in three patients (10%), and simultaneous involvement in the nasal cavity and naso/oropharynx in 13 patients (45%). Fourteen patients (48%) showed tumor extension into adjacent structures. Of the 26 patients with involvement of the nasal cavity, 18 (69%) presented with an infiltrative pattern, seven (27%) with a polypoid pattern, and one (4%) with a combined pattern. Areas of necrosis within the tumor were observed in six patients (21%), bone destruction in five (17%), and regional lymphadenopathies in two (7%).

CONCLUSION: Extranodal NKTL may be initially suggested by CT findings in the head and neck. Clinicians should consider these findings indicative of the possibility of NKTL, and should perform a histopathologic confirmation to establish a diagnosis.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ik(김동익)
Kim, Se Heon(김세헌)
Kim, Eung Yeop(김응엽)
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Choi, Eun Chang(최은창)
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