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Magnetoplex based on MnFe2O4 nanocrystals for magnetic labeling and MR imaging of human mesenchymal stem cells

Authors
 Jaemoon Yang  ;  Eun-Kyung Lim  ;  Eun-Sook Lee  ;  Jin-Suck Suh  ;  Seungjoo Haam  ;  Yong-Min Huh 
Citation
 JOURNAL OF NANOPARTICLE RESEARCH, Vol.12(4) : 1275-1283, 2010 
Journal Title
JOURNAL OF NANOPARTICLE RESEARCH
ISSN
 1388-0764 
Issue Date
2010
Keywords
Magnetic labeling ; Stem cell ; Ultrasensitive ; Monitoring ; Magnetic resonance imaging ; Nanomedicine
Abstract
For efficient labeling and tracking via magnetic resonance (MR) imaging of human mesenchymal stem cells (h-MSCs), magnetic labeling agents must be responsive to an external magnetic field. Thus, we developed ultrasensitive magnetoplex as a magnetic labeling agent composed of PEGylated MnFe2O4 nanocrystals (PMNCs) and polycationics (poly-l-lysine, PLL) for efficient labeling of the h-MSCs and monitoring of the transplanted h-MSCs for a long term. PMNCs were prepared by nanoemulsion methods composed of MnFe2O4 nanocrystals (MNCs) and amphiphilic polymers (mPEG–dodecanoic acid). The prepared PMNCs exhibited excellent biocompatibility and their polycationic complexes (PMNCs/PLL) demonstrated remarkable sensitivity compared with magnetic iron oxide nanoparticles (MION)/PLL or Ferumoxides/PLL. Furthermore, PMNCs demonstrated the potentials for novel diagnostic and therapeutic strategies with potential applications in various biomedical fields
Full Text
http://link.springer.com/article/10.1007%2Fs11051-009-9837-1#
DOI
10.1007/s11051-009-9837-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100827
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