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Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing

Authors
 Seung Hee Baek  ;  Young-Chang Kwon  ;  Hyangkyu Lee  ;  Kwang-Min Choe 
Citation
 Biochemical and Biophysical Research Communications, Vol.394(3) : 488-492, 2010 
Journal Title
 Biochemical and Biophysical Research Communications 
ISSN
 0006-291X 
Issue Date
2010
Abstract
A wound induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis. Here, we use myosin localization to demonstrate that Rac1, Cdc42, and Rho1 are each required for cell polarization and directional sensing of the wound. The three GTPases are also required for actin cable formation at the wound leading edge. Rac1, Cdc42, and Rho1 act upstream of c-Jun N-terminal kinase (JNK) to organize actin assembly. These results highlight the similarities between the molecular mechanism of Drosophila wound healing and those of Drosophila embryonic dorsal closure and the chemotactic response of Dictyostelium and leukocytes
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X1000358X
DOI
10.1016/j.bbrc.2010.02.124
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
이향규(Lee, Hyang Kyu) ORCID logo https://orcid.org/0000-0002-0821-6020
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100717
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