Cited 31 times in
Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing
DC Field | Value | Language |
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dc.contributor.author | 이향규 | - |
dc.date.accessioned | 2015-04-23T16:30:43Z | - |
dc.date.available | 2015-04-23T16:30:43Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100717 | - |
dc.description.abstract | A wound induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis. Here, we use myosin localization to demonstrate that Rac1, Cdc42, and Rho1 are each required for cell polarization and directional sensing of the wound. The three GTPases are also required for actin cable formation at the wound leading edge. Rac1, Cdc42, and Rho1 act upstream of c-Jun N-terminal kinase (JNK) to organize actin assembly. These results highlight the similarities between the molecular mechanism of Drosophila wound healing and those of Drosophila embryonic dorsal closure and the chemotactic response of Dictyostelium and leukocytes | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 488~492 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Actins/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Polarity* | - |
dc.subject.MESH | Drosophila Proteins/genetics | - |
dc.subject.MESH | Drosophila Proteins/physiology* | - |
dc.subject.MESH | Drosophila melanogaster/enzymology | - |
dc.subject.MESH | Drosophila melanogaster/physiology* | - |
dc.subject.MESH | JNK Mitogen-Activated Protein Kinases/metabolism | - |
dc.subject.MESH | Myosins/metabolism | - |
dc.subject.MESH | Wound Healing* | - |
dc.subject.MESH | cdc42 GTP-Binding Protein/genetics | - |
dc.subject.MESH | cdc42 GTP-Binding Protein/physiology* | - |
dc.subject.MESH | rac GTP-Binding Proteins/genetics | - |
dc.subject.MESH | rac GTP-Binding Proteins/physiology* | - |
dc.subject.MESH | rho GTP-Binding Proteins/genetics | - |
dc.subject.MESH | rho GTP-Binding Proteins/physiology* | - |
dc.title | Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Nursing Environment Systems (임상간호과학과) | - |
dc.contributor.googleauthor | Seung Hee Baek | - |
dc.contributor.googleauthor | Young-Chang Kwon | - |
dc.contributor.googleauthor | Hyangkyu Lee | - |
dc.contributor.googleauthor | Kwang-Min Choe | - |
dc.identifier.doi | 10.1016/j.bbrc.2010.02.124 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03282 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 20184864 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X1000358X | - |
dc.subject.keyword | Wound repair | - |
dc.subject.keyword | Zipper | - |
dc.subject.keyword | Actin cable | - |
dc.subject.keyword | Chemotaxis | - |
dc.contributor.alternativeName | Lee, Hyang Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Hyang Kyu | - |
dc.citation.volume | 394 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 488 | - |
dc.citation.endPage | 492 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.394(3) : 488-492, 2010 | - |
dc.identifier.rimsid | 37770 | - |
dc.type.rims | ART | - |
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