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Delayed enhancement magnetic resonance imaging is a significant prognostic factor in patients with non-ischemic cardiomyopathy.

 Jung Rae Cho  ;  Sungha Park  ;  Byoung Wook Choi  ;  Seok-Min Kang  ;  Jong-Won Ha  ;  Namsik Chung  ;  Kyu-Ok Choe  ;  Seung-Yun Cho  ;  Se-Joong Rim 
 CIRCULATION JOURNAL, Vol.74(3) : 476-483, 2010 
Journal Title
Issue Date
Adult ; Aged ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/mortality* ; Cardiomyopathies/pathology* ; Disease-Free Survival ; Echocardiography ; Female ; Fibrosis ; Follow-Up Studies ; Heart Failure/diagnostic imaging ; Heart Failure/mortality ; Heart Failure/pathology ; Heart Transplantation/statistics & numerical data ; Humans ; Kaplan-Meier Estimate ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Multivariate Analysis ; Myocardium/pathology* ; Patient Readmission/statistics & numerical data ; Predictive Value of Tests ; Prognosis ; Stroke Volume
Delayed enhancement ; Heart failure ; Magnetic resonance imaging ; Non-ischemic cardiomyopathy ; Prognosis
BACKGROUND: Delayed enhancement (DE) on cardiac magnetic resonance imaging (CMR) is a marker of myocardial fibrosis. The absence of DE in CMR is a predictor of left ventricular (LV) functional improvement in patients with non-ischemic cardiomyopathy (NICM), so in the present study it was investigated whether presence of DE has prognostic significance in patients with NICM at long-term follow-up.

METHODS AND RESULTS: The 79 patients (56.4+/-13.5 years, 48 males) with NICM (LV ejection fraction <35%, no significant coronary artery disease) were monitored for occurrence of cardiac events. CMR was performed to assess DE. Cardiac events were defined as rehospitalization (because of worsening of heart failure), cardiac transplantation or death. There were 37 patients without and 42 patients with DE. The mean follow-up duration was 19+/-10 months. There was 1 event (2.7%, 1 rehospitalization) in the DE (-) group, whereas 13 events (30.9%, 1 death, 1 transplantation, 11 rehospitalizations) occurred in the DE (+) group. The event-free survival was significantly longer in the DE (-) group than in the DE (+) group (38.9+/-1.0 vs 28.4+/-2.7 months, P<0.01). Multivariate regression analysis revealed that presence of DE was the most potent, independent predictor of cardiac events (hazard ratio 8.06, confidence interval 1.03+/-63.41, P<0.05).

CONCLUSIONS: The presence of DE in CMR is a significant predictor of future cardiac events in patients with NICM.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Chung, Nam Sik(정남식)
Cho, Seung Yun(조승연)
Choe, Kyu Ok(최규옥)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
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