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Nonmuscle myosin II localization is regulated by JNK during Drosophila larval wound healing

Authors
 Young-Chang Kwon  ;  Seung Hee Baek  ;  Hyangkyu Lee  ;  Kwang-Min Choe 
Citation
 Biochemical and Biophysical Research Communications, Vol.393(4) : 656-661, 2010 
Journal Title
 Biochemical and Biophysical Research Communications 
ISSN
 0006-291X 
Issue Date
2010
MeSH
Animals ; Cell Shape ; Drosophila Proteins/metabolism* ; Drosophila melanogaster/cytology ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/physiology* ; Epidermis/metabolism ; Epidermis/physiology* ; JNK Mitogen-Activated Protein Kinases/genetics ; JNK Mitogen-Activated Protein Kinases/metabolism* ; Larva/metabolism ; Larva/physiology ; Membrane Proteins/metabolism* ; Myosin Heavy Chains/metabolism* ; Wound Healing*
Keywords
Wound repair ; Zipper ; Actin cable ; Chemotaxis
Abstract
We investigated cell shape changes during wound closure in the Drosophila larval epidermis. During reepithelialization, epidermal cells permanently change shape from pentagonal or hexagonal to irregular forms. This process requires zipper, a gene encoding the Drosophila nonmuscle myosin II heavy chain. Following wounding, myosin II is localized at the wound margin and at the rear end of individual cells located within several rows from the wound hole. The c-Jun N-terminal kinase (JNK) pathway is essential for this myosin II localization. These results suggest that not only the wound leading edge but also the cells lying distal to the leading edge cells actively participate in epithelial cell sheet migration during wound hole closure
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X10002585
DOI
10.1016/j.bbrc.2010.02.047
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Lee, Hyang Kyu(이향규) ORCID logo https://orcid.org/0000-0002-0821-6020
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100676
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