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Circulating endothelial progenitor cells (EPC) for tumor vasculogenesis in gastric cancer patients

Authors
 Joong Bae Ahn  ;  Sun Young Rha  ;  Sang Joon Shin  ;  Hei-Cheul Jeung  ;  Tae Soo Kim  ;  Xianglan Zhang  ;  Kyu Hyun Park  ;  Sung Hoon Noh  ;  Jae Kyung Roh  ;  Hyun Cheol Chung 
Citation
 CANCER LETTERS, Vol.288(1) : 124-132, 2010 
Journal Title
CANCER LETTERS
ISSN
 0304-3835 
Issue Date
2010
MeSH
AC133 Antigen ; Animals ; Antigens, CD/metabolism ; Antigens, CD34/metabolism ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biological Transport ; Biomarkers/metabolism ; Cell Differentiation ; Cell Line,Tumor ; Cell Movement ; Cell Proliferation ; Cell Separation ; EndothelialCells/immunology ; EndothelialCells/pathology* ; EndothelialCells/transplantation ; Female ; Glycoproteins/metabolism ; Humans ; Lipoproteins, LDL/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neovascularization, Pathologic/pathology* ; Peptides/metabolism ; Stem Cell Transplantation ; StemCells/immunology ; StemCells/pathology* ; Stomach Neoplasms/blood supply* ; Stomach Neoplasms/drug therapy ; Telomerase/metabolism ; Time Factors
Keywords
Endothelial progenitor cells ; CD34 ; Vasculogenesis ; Angiogenesis
Abstract
It has been suggested that vasculogenesis by endothelial progenitor cells (EPC) as well as angiogenesis play an important role in the production of blood vessels in neoplasm. The present study was designed to isolate and characterize the EPC in gastric cancer patients as a tumor specific angiogenesis marker. The cells derived from CD34 positive PBMC presented with a cobblestone appearance at 28 days, revealing differentiation into endothelial cells. They were also positive to the LDL-uptake reaction, showing that they have biological endothelial cell functions. These cells demonstrated tube formation, showing their ability to participate in neovascularization. The cells derived from CD34 positive PBMC expressed CD133 and demonstrated telomerase activity, showing the stem cell character. In xenograft model, EPC derived from CD34 positive PBMC mobilized mainly into tumor area after being injected through tail vein. With isolation, ex vivo amplification and characterization of EPC from gastric cancer patients receiving chemotherapy, endothelial progenitor cells may be used as a candidate prognostic and predictive biomarker for cancer
Full Text
http://www.sciencedirect.com/science/article/pii/S0304383509004571
DOI
10.1016/j.canlet.2009.06.031
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100460
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