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Circulating endothelial progenitor cells (EPC) for tumor vasculogenesis in gastric cancer patients

DC FieldValueLanguage
dc.contributor.author노성훈-
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author신상준-
dc.contributor.author안중배-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.date.accessioned2015-04-23T16:22:16Z-
dc.date.available2015-04-23T16:22:16Z-
dc.date.issued2010-
dc.identifier.issn0304-3835-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100460-
dc.description.abstractIt has been suggested that vasculogenesis by endothelial progenitor cells (EPC) as well as angiogenesis play an important role in the production of blood vessels in neoplasm. The present study was designed to isolate and characterize the EPC in gastric cancer patients as a tumor specific angiogenesis marker. The cells derived from CD34 positive PBMC presented with a cobblestone appearance at 28 days, revealing differentiation into endothelial cells. They were also positive to the LDL-uptake reaction, showing that they have biological endothelial cell functions. These cells demonstrated tube formation, showing their ability to participate in neovascularization. The cells derived from CD34 positive PBMC expressed CD133 and demonstrated telomerase activity, showing the stem cell character. In xenograft model, EPC derived from CD34 positive PBMC mobilized mainly into tumor area after being injected through tail vein. With isolation, ex vivo amplification and characterization of EPC from gastric cancer patients receiving chemotherapy, endothelial progenitor cells may be used as a candidate prognostic and predictive biomarker for cancer-
dc.description.statementOfResponsibilityopen-
dc.format.extent124~132-
dc.relation.isPartOfCancer Letters-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAC133 Antigen-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, CD/metabolism-
dc.subject.MESHAntigens, CD34/metabolism-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use-
dc.subject.MESHBiological Transport-
dc.subject.MESHBiomarkers/metabolism-
dc.subject.MESHCell Differentiation-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Movement-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCell Separation-
dc.subject.MESHEndothelial Cells/immunology-
dc.subject.MESHEndothelial Cells/pathology*-
dc.subject.MESHEndothelial Cells/transplantation-
dc.subject.MESHFemale-
dc.subject.MESHGlycoproteins/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHLipoproteins, LDL/metabolism-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Nude-
dc.subject.MESHNeovascularization, Pathologic/pathology*-
dc.subject.MESHPeptides/metabolism-
dc.subject.MESHStem Cell Transplantation-
dc.subject.MESHStem Cells/immunology-
dc.subject.MESHStem Cells/pathology*-
dc.subject.MESHStomach Neoplasms/blood supply*-
dc.subject.MESHStomach Neoplasms/drug therapy-
dc.subject.MESHTelomerase/metabolism-
dc.subject.MESHTime Factors-
dc.titleCirculating endothelial progenitor cells (EPC) for tumor vasculogenesis in gastric cancer patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorSang Joon Shin-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorTae Soo Kim-
dc.contributor.googleauthorXianglan Zhang-
dc.contributor.googleauthorKyu Hyun Park-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorJae Kyung Roh-
dc.contributor.googleauthorHyun Cheol Chung-
dc.identifier.doi10.1016/j.canlet.2009.06.031-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01281-
dc.contributor.localIdA01290-
dc.contributor.localIdA02105-
dc.contributor.localIdA02262-
dc.contributor.localIdA03773-
dc.contributor.localIdA03794-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ00448-
dc.identifier.pmid19619937-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304383509004571-
dc.subject.keywordEndothelial progenitor cells-
dc.subject.keywordCD34-
dc.subject.keywordVasculogenesis-
dc.subject.keywordAngiogenesis-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameShin, Sang Joon-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorShin, Sang Joon-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.citation.volume288-
dc.citation.number1-
dc.citation.startPage124-
dc.citation.endPage132-
dc.identifier.bibliographicCitationCancer Letters, Vol.288(1) : 124-132, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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