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Ocular surface inflammation, and nerve growth factor level in tears in active thyroid-associated ophthalmopathy

Authors
 Jin Sook Yoon  ;  Soo Hyun Choi  ;  Joon H. Lee  ;  Sung Jun Lee  ;  Sang Yeul Lee 
Citation
 GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.248(2) : 271-276, 2010 
Journal Title
 GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 
ISSN
 0721-832X 
Issue Date
2010
MeSH
Adolescent ; Adult ; Aged ; Autoantibodies/blood ; Female ; Glucocorticoids/therapeutic use ; Graves Ophthalmopathy/complications* ; Graves Ophthalmopathy/immunology ; Humans ; Hyperthyroidism/complications ; Hyperthyroidism/immunology ; Male ; Middle Aged ; Nerve Growth Factor/metabolism* ; Scleritis/drug therapy ; Scleritis/etiology* ; Scleritis/metabolism* ; Tears/immunology ; Tears/metabolism* ; Thyroiditis, Autoimmune/complications ; Thyroiditis, Autoimmune/immunology ; Young Adult
Keywords
Glucocorticoid  ; Nerve growth factor ;  Tear  ; Thyroid-associated ophthalmopathy 
Abstract
PURPOSE: To measure tear nerve growth factor (NGF) concentrations in cases of active thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid treatment, and to correlate NGF levels with disease inflammatory activity and thyroid autoantibody concentration. METHODS: The study involved 20 patients with active TAO and 20 age- and gender-matched controls. Tear break-up time (BUT) was obtained, the Schirmer test was performed, and tear NGF/total protein ratio was measured in control subjects and patients with active TAO before, and 2 and 4 weeks after, steroid treatment. RESULTS: Tear BUT and Schirmer values significantly increased after 2 and 4 weeks of steroid treatment (p < 0.001 and p = 0.004 respectively). Baseline tear NGF/total protein ratio was higher in patients with active TAO than in control subjects, and the ratio significantly decreased after 2 and 4 weeks of steroid treatment (p < 0.001). Tear NGF/total protein ratio did not correlate with inflammatory activity score, exophthalmos value and thyroid binding inhibiting immunoglobulin (TBII) level (p > 0.05). CONCLUSIONS: Tear NGF may have a specific role in ocular surface inflammation, which protects against ocular surface damage in patients with active TAO. Anti-inflammatory treatment significantly reduced the level of NGF in tears, increased tear film stability and production, and decreased congestive symptoms.
Full Text
http://link.springer.com/article/10.1007%2Fs00417-009-1215-2
DOI
10.1007/s00417-009-1215-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
Lee, Sang Yeul(이상열)
Lee, Sung Jun(이성준)
Lee, Joon Haeng(이준행)
Choi, Soo Hyun(최수현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100433
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