Cited 26 times in
Ocular surface inflammation, and nerve growth factor level in tears in active thyroid-associated ophthalmopathy
DC Field | Value | Language |
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dc.contributor.author | 윤진숙 | - |
dc.contributor.author | 이상열 | - |
dc.contributor.author | 최수현 | - |
dc.date.accessioned | 2015-04-23T16:21:22Z | - |
dc.date.available | 2015-04-23T16:21:22Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0721-832X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100433 | - |
dc.description.abstract | PURPOSE: To measure tear nerve growth factor (NGF) concentrations in cases of active thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid treatment, and to correlate NGF levels with disease inflammatory activity and thyroid autoantibody concentration. METHODS: The study involved 20 patients with active TAO and 20 age- and gender-matched controls. Tear break-up time (BUT) was obtained, the Schirmer test was performed, and tear NGF/total protein ratio was measured in control subjects and patients with active TAO before, and 2 and 4 weeks after, steroid treatment. RESULTS: Tear BUT and Schirmer values significantly increased after 2 and 4 weeks of steroid treatment (p < 0.001 and p = 0.004 respectively). Baseline tear NGF/total protein ratio was higher in patients with active TAO than in control subjects, and the ratio significantly decreased after 2 and 4 weeks of steroid treatment (p < 0.001). Tear NGF/total protein ratio did not correlate with inflammatory activity score, exophthalmos value and thyroid binding inhibiting immunoglobulin (TBII) level (p > 0.05). CONCLUSIONS: Tear NGF may have a specific role in ocular surface inflammation, which protects against ocular surface damage in patients with active TAO. Anti-inflammatory treatment significantly reduced the level of NGF in tears, increased tear film stability and production, and decreased congestive symptoms. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Autoantibodies/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucocorticoids/therapeutic use | - |
dc.subject.MESH | GravesOphthalmopathy/complications* | - |
dc.subject.MESH | GravesOphthalmopathy/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperthyroidism/complications | - |
dc.subject.MESH | Hyperthyroidism/immunology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | NerveGrowthFactor/metabolism* | - |
dc.subject.MESH | Scleritis/drug therapy | - |
dc.subject.MESH | Scleritis/etiology* | - |
dc.subject.MESH | Scleritis/metabolism* | - |
dc.subject.MESH | Tears/immunology | - |
dc.subject.MESH | Tears/metabolism* | - |
dc.subject.MESH | Thyroiditis, Autoimmune/complications | - |
dc.subject.MESH | Thyroiditis, Autoimmune/immunology | - |
dc.subject.MESH | Young Adult | - |
dc.title | Ocular surface inflammation, and nerve growth factor level in tears in active thyroid-associated ophthalmopathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Jin Sook Yoon | - |
dc.contributor.googleauthor | Soo Hyun Choi | - |
dc.contributor.googleauthor | Joon H. Lee | - |
dc.contributor.googleauthor | Sung Jun Lee | - |
dc.contributor.googleauthor | Sang Yeul Lee | - |
dc.identifier.doi | 10.1007/s00417-009-1215-2 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02611 | - |
dc.contributor.localId | A02819 | - |
dc.contributor.localId | A03180 | - |
dc.contributor.localId | A04094 | - |
dc.contributor.localId | A02871 | - |
dc.relation.journalcode | J00951 | - |
dc.identifier.eissn | 1435-702X | - |
dc.identifier.pmid | 19844736 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00417-009-1215-2 | - |
dc.subject.keyword | Glucocorticoid | - |
dc.subject.keyword | Nerve growth factor | - |
dc.subject.keyword | Tear | - |
dc.subject.keyword | Thyroid-associated ophthalmopathy | - |
dc.contributor.alternativeName | Yoon, Jin Sook | - |
dc.contributor.alternativeName | Lee, Sang Yeul | - |
dc.contributor.alternativeName | Choi, Soo Hyun | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Sook | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeul | - |
dc.contributor.affiliatedAuthor | Choi, Soo Hyun | - |
dc.citation.volume | 248 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 271 | - |
dc.citation.endPage | 276 | - |
dc.identifier.bibliographicCitation | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.248(2) : 271-276, 2010 | - |
dc.identifier.rimsid | 36483 | - |
dc.type.rims | ART | - |
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