2 360

Cited 19 times in

Ocular surface inflammation, and nerve growth factor level in tears in active thyroid-associated ophthalmopathy

DC Field Value Language
dc.contributor.author윤진숙-
dc.contributor.author이상열-
dc.contributor.author이성준-
dc.contributor.author이준행-
dc.contributor.author최수현-
dc.date.accessioned2015-04-23T16:21:22Z-
dc.date.available2015-04-23T16:21:22Z-
dc.date.issued2010-
dc.identifier.issn0721-832X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100433-
dc.description.abstractPURPOSE: To measure tear nerve growth factor (NGF) concentrations in cases of active thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid treatment, and to correlate NGF levels with disease inflammatory activity and thyroid autoantibody concentration. METHODS: The study involved 20 patients with active TAO and 20 age- and gender-matched controls. Tear break-up time (BUT) was obtained, the Schirmer test was performed, and tear NGF/total protein ratio was measured in control subjects and patients with active TAO before, and 2 and 4 weeks after, steroid treatment. RESULTS: Tear BUT and Schirmer values significantly increased after 2 and 4 weeks of steroid treatment (p < 0.001 and p = 0.004 respectively). Baseline tear NGF/total protein ratio was higher in patients with active TAO than in control subjects, and the ratio significantly decreased after 2 and 4 weeks of steroid treatment (p < 0.001). Tear NGF/total protein ratio did not correlate with inflammatory activity score, exophthalmos value and thyroid binding inhibiting immunoglobulin (TBII) level (p > 0.05). CONCLUSIONS: Tear NGF may have a specific role in ocular surface inflammation, which protects against ocular surface damage in patients with active TAO. Anti-inflammatory treatment significantly reduced the level of NGF in tears, increased tear film stability and production, and decreased congestive symptoms.-
dc.description.statementOfResponsibilityopen-
dc.format.extent271~276-
dc.relation.isPartOfGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAutoantibodies/blood-
dc.subject.MESHFemale-
dc.subject.MESHGlucocorticoids/therapeutic use-
dc.subject.MESHGravesOphthalmopathy/complications*-
dc.subject.MESHGravesOphthalmopathy/immunology-
dc.subject.MESHHumans-
dc.subject.MESHHyperthyroidism/complications-
dc.subject.MESHHyperthyroidism/immunology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNerveGrowthFactor/metabolism*-
dc.subject.MESHScleritis/drug therapy-
dc.subject.MESHScleritis/etiology*-
dc.subject.MESHScleritis/metabolism*-
dc.subject.MESHTears/immunology-
dc.subject.MESHTears/metabolism*-
dc.subject.MESHThyroiditis, Autoimmune/complications-
dc.subject.MESHThyroiditis, Autoimmune/immunology-
dc.subject.MESHYoung Adult-
dc.titleOcular surface inflammation, and nerve growth factor level in tears in active thyroid-associated ophthalmopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorJin Sook Yoon-
dc.contributor.googleauthorSoo Hyun Choi-
dc.contributor.googleauthorJoon H. Lee-
dc.contributor.googleauthorSung Jun Lee-
dc.contributor.googleauthorSang Yeul Lee-
dc.identifier.doi10.1007/s00417-009-1215-2-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02611-
dc.contributor.localIdA02819-
dc.contributor.localIdA03180-
dc.contributor.localIdA04094-
dc.contributor.localIdA02871-
dc.relation.journalcodeJ00951-
dc.identifier.eissn1435-702X-
dc.identifier.pmid19844736-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00417-009-1215-2-
dc.subject.keywordGlucocorticoid-
dc.subject.keywordNerve growth factor-
dc.subject.keywordTear-
dc.subject.keywordThyroid-associated ophthalmopathy-
dc.contributor.alternativeNameYoon, Jin Sook-
dc.contributor.alternativeNameLee, Sang Yeul-
dc.contributor.alternativeNameLee, Sung Jun-
dc.contributor.alternativeNameLee, Joon Haeng-
dc.contributor.alternativeNameChoi, Soo Hyun-
dc.contributor.affiliatedAuthorYoon, Jin Sook-
dc.contributor.affiliatedAuthorLee, Sang Yeul-
dc.contributor.affiliatedAuthorLee, Joon Haeng-
dc.contributor.affiliatedAuthorChoi, Soo Hyun-
dc.contributor.affiliatedAuthorLee, Sung Jun-
dc.citation.volume248-
dc.citation.number2-
dc.citation.startPage271-
dc.citation.endPage276-
dc.identifier.bibliographicCitationGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.248(2) : 271-276, 2010-
dc.identifier.rimsid36483-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.