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Urine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women

 Jee-Yon Lee  ;  Duk-Chul Lee 
 MATURITAS, Vol.78(2) : 117-122, 2014 
Journal Title
Issue Date
Aging ; Atherosclerosis/urine ; Female ; Humans ; Logistic Models ; Melatonin/analogs & derivatives* ; Melatonin/secretion ; Melatonin/urine ; Middle Aged ; Odds Ratio ; Postmenopause/urine ; Prospective Studies ; Risk Factors ; Vascular Stiffness*
6-Sulfatoxymelatonin ; Arterial stiffness ; Atherosclerosis ; Melatonin ; Menopause
OBJECT: The secretion of melatonin, a pleiotropic hormone mainly synthesized by the pineal gland, typically decreases with age and may be associated with the development of aging-related pathologic conditions such as cardiovascular disease. Atherosclerosis is an aging-related disease, the pathogenesis of which involves chronic inflammation and increased oxidative stress. Since melatonin has both anti-oxidant and anti-inflammatory properties, it may be associated with atherosclerosis. Therefore, we investigated the relationship between urine concentrations of 6-sulfatoxymelatonin (aMT6s) and arterial stiffness in post-menopausal women. METHODS: A total of 66 post-menopausal women participated in the study. Melatonin secretion was estimated by measuring aMT6s levels in first morning urine samples. The cardio-ankle vascular index (CAVI) was used as an indicator of arterial stiffness. RESULTS: Estimated mean CAVI decreased gradually with increasing aMT6s quartiles. The multivariate logistic regression analysis showed that the fourth aMT6s quartile was associated with a high CAVI with an adjusted odds ratio of 0.03 (95% confidence interval, 0.01-0.47). CONCLUSION: Our study revealed an inverse relationship between urine aMT6s and arterial stiffness as determined by CAVI. Although it is impossible to determine causality, our results suggest that melatonin may have a beneficial role in the pathogenesis of atherosclerosis. Further prospective studies are required to establish the clinical significance of our study.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Jee Yon(이지연)
Lee, Chang Kyu(이창규)
Hong, Sa Min(홍사민)
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