Cited 5 times in
Urine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women
DC Field | Value | Language |
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dc.contributor.author | 김찬윤 | - |
dc.contributor.author | 성공제 | - |
dc.contributor.author | 이덕철 | - |
dc.contributor.author | 이지연 | - |
dc.contributor.author | 이창규 | - |
dc.contributor.author | 홍사민 | - |
dc.date.accessioned | 2015-01-06T17:37:56Z | - |
dc.date.available | 2015-01-06T17:37:56Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0378-5122 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100340 | - |
dc.description.abstract | OBJECT: The secretion of melatonin, a pleiotropic hormone mainly synthesized by the pineal gland, typically decreases with age and may be associated with the development of aging-related pathologic conditions such as cardiovascular disease. Atherosclerosis is an aging-related disease, the pathogenesis of which involves chronic inflammation and increased oxidative stress. Since melatonin has both anti-oxidant and anti-inflammatory properties, it may be associated with atherosclerosis. Therefore, we investigated the relationship between urine concentrations of 6-sulfatoxymelatonin (aMT6s) and arterial stiffness in post-menopausal women. METHODS: A total of 66 post-menopausal women participated in the study. Melatonin secretion was estimated by measuring aMT6s levels in first morning urine samples. The cardio-ankle vascular index (CAVI) was used as an indicator of arterial stiffness. RESULTS: Estimated mean CAVI decreased gradually with increasing aMT6s quartiles. The multivariate logistic regression analysis showed that the fourth aMT6s quartile was associated with a high CAVI with an adjusted odds ratio of 0.03 (95% confidence interval, 0.01-0.47). CONCLUSION: Our study revealed an inverse relationship between urine aMT6s and arterial stiffness as determined by CAVI. Although it is impossible to determine causality, our results suggest that melatonin may have a beneficial role in the pathogenesis of atherosclerosis. Further prospective studies are required to establish the clinical significance of our study. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 117~122 | - |
dc.relation.isPartOf | MATURITAS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aging | - |
dc.subject.MESH | Atherosclerosis/urine | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Melatonin/analogs & derivatives* | - |
dc.subject.MESH | Melatonin/secretion | - |
dc.subject.MESH | Melatonin/urine | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Postmenopause/urine | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Vascular Stiffness* | - |
dc.title | Urine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | Jee-Yon Lee | - |
dc.contributor.googleauthor | Duk-Chul Lee | - |
dc.identifier.doi | 10.1016/j.maturitas.2014.03.010 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01035 | - |
dc.contributor.localId | A01946 | - |
dc.contributor.localId | A02716 | - |
dc.contributor.localId | A03196 | - |
dc.contributor.localId | A04395 | - |
dc.contributor.localId | A03241 | - |
dc.relation.journalcode | J02190 | - |
dc.identifier.eissn | 1873-4111 | - |
dc.identifier.pmid | 24780409 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0378512214001182 | - |
dc.subject.keyword | 6-Sulfatoxymelatonin | - |
dc.subject.keyword | Arterial stiffness | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Melatonin | - |
dc.subject.keyword | Menopause | - |
dc.contributor.alternativeName | Kim, Chan Yun | - |
dc.contributor.alternativeName | Seong, Gong Je | - |
dc.contributor.alternativeName | Lee, Duk Chul | - |
dc.contributor.alternativeName | Lee, Jee Yon | - |
dc.contributor.alternativeName | Lee, Chang Kyu | - |
dc.contributor.alternativeName | Hong, Sa Min | - |
dc.contributor.affiliatedAuthor | Kim, Chan Yun | - |
dc.contributor.affiliatedAuthor | Seong, Gong Je | - |
dc.contributor.affiliatedAuthor | Lee, Duk Chul | - |
dc.contributor.affiliatedAuthor | Lee, Jee Yon | - |
dc.contributor.affiliatedAuthor | Hong, Sa Min | - |
dc.contributor.affiliatedAuthor | Lee, Chang Kyu | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 78 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 117 | - |
dc.citation.endPage | 122 | - |
dc.identifier.bibliographicCitation | MATURITAS, Vol.78(2) : 117-122, 2014 | - |
dc.identifier.rimsid | 57601 | - |
dc.type.rims | ART | - |
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