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Urine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women

DC Field Value Language
dc.contributor.author김찬윤-
dc.contributor.author성공제-
dc.contributor.author이덕철-
dc.contributor.author이지연-
dc.contributor.author이창규-
dc.contributor.author홍사민-
dc.date.accessioned2015-01-06T17:37:56Z-
dc.date.available2015-01-06T17:37:56Z-
dc.date.issued2014-
dc.identifier.issn0378-5122-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100340-
dc.description.abstractOBJECT: The secretion of melatonin, a pleiotropic hormone mainly synthesized by the pineal gland, typically decreases with age and may be associated with the development of aging-related pathologic conditions such as cardiovascular disease. Atherosclerosis is an aging-related disease, the pathogenesis of which involves chronic inflammation and increased oxidative stress. Since melatonin has both anti-oxidant and anti-inflammatory properties, it may be associated with atherosclerosis. Therefore, we investigated the relationship between urine concentrations of 6-sulfatoxymelatonin (aMT6s) and arterial stiffness in post-menopausal women. METHODS: A total of 66 post-menopausal women participated in the study. Melatonin secretion was estimated by measuring aMT6s levels in first morning urine samples. The cardio-ankle vascular index (CAVI) was used as an indicator of arterial stiffness. RESULTS: Estimated mean CAVI decreased gradually with increasing aMT6s quartiles. The multivariate logistic regression analysis showed that the fourth aMT6s quartile was associated with a high CAVI with an adjusted odds ratio of 0.03 (95% confidence interval, 0.01-0.47). CONCLUSION: Our study revealed an inverse relationship between urine aMT6s and arterial stiffness as determined by CAVI. Although it is impossible to determine causality, our results suggest that melatonin may have a beneficial role in the pathogenesis of atherosclerosis. Further prospective studies are required to establish the clinical significance of our study.-
dc.description.statementOfResponsibilityopen-
dc.format.extent117~122-
dc.relation.isPartOfMATURITAS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAging-
dc.subject.MESHAtherosclerosis/urine-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHMelatonin/analogs & derivatives*-
dc.subject.MESHMelatonin/secretion-
dc.subject.MESHMelatonin/urine-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPostmenopause/urine-
dc.subject.MESHProspective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHVascular Stiffness*-
dc.titleUrine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorJee-Yon Lee-
dc.contributor.googleauthorDuk-Chul Lee-
dc.identifier.doi10.1016/j.maturitas.2014.03.010-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01035-
dc.contributor.localIdA01946-
dc.contributor.localIdA02716-
dc.contributor.localIdA03196-
dc.contributor.localIdA04395-
dc.contributor.localIdA03241-
dc.relation.journalcodeJ02190-
dc.identifier.eissn1873-4111-
dc.identifier.pmid24780409-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0378512214001182-
dc.subject.keyword6-Sulfatoxymelatonin-
dc.subject.keywordArterial stiffness-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordMelatonin-
dc.subject.keywordMenopause-
dc.contributor.alternativeNameKim, Chan Yun-
dc.contributor.alternativeNameSeong, Gong Je-
dc.contributor.alternativeNameLee, Duk Chul-
dc.contributor.alternativeNameLee, Jee Yon-
dc.contributor.alternativeNameLee, Chang Kyu-
dc.contributor.alternativeNameHong, Sa Min-
dc.contributor.affiliatedAuthorKim, Chan Yun-
dc.contributor.affiliatedAuthorSeong, Gong Je-
dc.contributor.affiliatedAuthorLee, Duk Chul-
dc.contributor.affiliatedAuthorLee, Jee Yon-
dc.contributor.affiliatedAuthorHong, Sa Min-
dc.contributor.affiliatedAuthorLee, Chang Kyu-
dc.rights.accessRightsfree-
dc.citation.volume78-
dc.citation.number2-
dc.citation.startPage117-
dc.citation.endPage122-
dc.identifier.bibliographicCitationMATURITAS, Vol.78(2) : 117-122, 2014-
dc.identifier.rimsid57601-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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