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Systemic Hypertension as a Risk Factor for Open-Angle Glaucoma: A Meta-Analysis of Population-Based Studies

 Hyoung Won Bae  ;  Naeun Lee  ;  Hye Sun Lee  ;  Samin Hong  ;  Gong Je Seong  ;  Chan Yun Kim 
 PLOS ONE, Vol.9(9) : e108226, 2014 
Journal Title
Issue Date
Asian Continental Ancestry Group ; European Continental Ancestry Group ; Glaucoma, Open-Angle/epidemiology* ; Glaucoma, Open-Angle/etiology* ; Humans ; Hypertension/complications* ; Odds Ratio ; Population Surveillance ; Publication Bias ; Risk Factors
BACKGROUND/AIMS: Systemic hypertension is thought to increase the risk for developing open-angle glaucoma (OAG) through several mechanisms. However, previous epidemiological studies have shown conflicting results regarding this potential association. We systematically evaluated this issue by conducting a meta-analysis of population-based studies. METHODS: A comprehensive search for articles published before 31 March 2014 was performed using PubMed, Embase, and reference lists. The pooled odds ratio (OR) was calculated using the fixed- and random-effects models, and meta-regression was performed according to age. Subgroup analyses were also conducted, and publication bias was assessed using a funnel plot and Egger's regression test. RESULTS: This meta-analysis included 16 studies involving 60,084 individuals, with substantial homogeneity among the studies. The pooled OR for OAG was 1.22 (95% confidence interval, CI: 1.09-1.36) using the fixed-effects model and 1.22 (95% CI: 1.08-1.37) using the random-effects model in all included studies. For subgroup analyses, the pooled OR for high-tension glaucoma (HTG) was higher than that for normal-tension glaucoma (NTG) (OR=1.92 and 0.94, respectively). No significant difference was detected between Asian and Western populations, and no publication bias was detected in either analysis. CONCLUSIONS: Systemic hypertension increases the risk for developing OAG, especially in those with HTG.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Na Eun(이나은)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Hong, Sa Min(홍사민)
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