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Associations of the BRAFV600E Mutation with Sonographic Features and Clinicopathologic Characteristics in a Large Population with Conventional Papillary Thyroid Carcinoma

 Ah Young Park  ;  Eun Ju Son  ;  Jeong-Ah Kim  ;  Ji Hyun Youk  ;  Yun Joo Park  ;  Cheong Soo Park  ;  Hang Seok Chang 
 PLOS ONE, Vol.9(10) : e110868, 2014 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Papillary/diagnostic imaging ; Carcinoma, Papillary/genetics* ; Carcinoma, Papillary/secondary ; Female ; Genetic Association Studies ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Mutation, Missense* ; Proto-Oncogene Proteins B-raf/genetics* ; Retrospective Studies ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/genetics* ; Thyroid Neoplasms/pathology ; Tumor Burden ; Ultrasonography ; Young Adult
OBJECTIVE: To evaluate the association of the BRAFV600E mutation with sonographic features and clinicopathologic characteristics in a large population with conventional papillary thyroid carcinoma (PTC). METHODS: We retrospectively reviewed the sonographic features, clinicopathologic characteristics, and presence of the BRAFV600E mutation in 688 patients who underwent thyroidectomy for conventional PTC between January and July 2010 at a single institution. The incidence of the BRAFV600E mutation was calculated. The sonographic features and clinicopathologic characteristics were compared between BRAF-positive and BRAF-negative patients. BRAF-positive patients were subdivided into those with papillary thyroid microcarcinoma (the PTMC group) and those with PTC larger than 10 mm (the PTC>10 mm group), and their sonographic features were compared. RESULTS: The BRAFV600E mutation was detected in 69.2% of patients (476 of 688). Sonographic features were not significantly different between BRAF-positive and BRAF-negative PTC, nor between PTMC and PTC>10 mm groups. The BRAFV600E mutation was associated with male sex (P = 0.028), large tumor size, extrathyroidal extension, central and lateral lymph node metastasis, and advanced tumor stage (P<0.0001). CONCLUSION: The BRAFV600E mutation was significantly associated with several poor clinicopathologic characteristics, but was not associated with sonographic features, regardless of tumor size. We recommend that patients with a thyroid nodule with any suspicious sonographic feature undergo preoperative BRAFV600E testing for risk stratification and to guide the initial surgical approach in PTC.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ah(김정아) ORCID logo https://orcid.org/0000-0003-4949-4913
Park, Ah Young(박아영)
Park, Yun Joo(박연주)
Park, Cheong Soo(박정수)
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
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