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Points to Be Considered When Applying FibroScan S Probe in Children with Biliary Atresia.

 Seung Kim  ;  Yunkoo Kang  ;  Mi Jung Lee  ;  Myung Joon Kim  ;  Seok Joo Han  ;  Hong Koh 
 Journal of Pediatric Gastroenterology and Nutrition, Vol.59(5) : 624-628, 2014 
Journal Title
 Journal of Pediatric Gastroenterology and Nutrition 
Issue Date
Adolescent ; Aspartate Aminotransferases/blood ; Biliary Atresia/blood ; Biliary Atresia/pathology* ; Blood Platelets ; Child ; Child, Preschool ; Elasticity Imaging Techniques/methods* ; Female ; Humans ; Infant ; Infant, Newborn ; Liver/enzymology ; Liver/pathology* ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis* ; Male ; Thorax*
biliary atresia ; children ; liver fibrosis ; transient elastography
OBJECTIVES: With the introduction of smaller probes (S1, S2), the use of transient elastography has been expanded to children. Accordingly, we aimed to address points of consideration in probe choice and interpretation of measured liver stiffness by applying and comparing FibroScan S and M probes in biliary atresia. METHODS: Using S1, S2, and M probes, 3 liver stiffness measurements, success rates, and interquartile ranges were obtained from 100 patients. Patients were assigned to 2 groups according to thoracic perimeter (≤45 cm vs >45 cm). In both groups, obtained values were compared and the relation between liver stiffness measurement and aspartate aminotransferase-to-platelet ratio index was analyzed. RESULTS: In the small-thorax group, the success rate was highest with the S1 probe and the intraclass correlation coefficient (ICC) was highest for S1 versus S2 (0.98), compared with that for S1 versus M (0.69) and S2 versus M (0.77). In the large-thorax group, ICC was the highest for S2 versus M (0.88), compared with that for S1 versus S2 (0.69) and S1 versus M (0.51). In the small-thorax group, correlations between aspartate aminotransferase-to-platelet ratio index and liver stiffness measurement were stronger for S1 (0.65) and S2 (0.64) than for M (0.49). In the large-thorax group, all probes showed good correlation, S1 (0.68), S2 (0.62), and M (0.62). CONCLUSIONS: We recommend that the S1 probe is more appropriate for use in small children, especially those with a thorax perimeter of <45 cm. If no S probe is available, the M probe may be acceptable in children whose thorax perimeter is >45 cm.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Yunkoo(강윤구) ORCID logo https://orcid.org/0000-0003-1712-2138
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
Kim, Myung Joon(김명준) ORCID logo https://orcid.org/0000-0002-4608-0275
Kim, Seung(김승) ORCID logo https://orcid.org/0000-0003-4373-9828
Lee, Mi-Jung(이미정) ORCID logo https://orcid.org/0000-0003-3244-9171
Han, Seok Joo(한석주) ORCID logo https://orcid.org/0000-0001-5224-1437
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