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백내장 수술 전후 0.05% 사이클로스포린 점안이 눈물막 및각막수차에 미치는 영향

Other Titles
 Effect of Cyclosporin A on Tear Film and Corneal Aberration after Cataract Surgery 
Authors
 전제훈  ;  김홍석  ;  정지원  ;  윤상철  ;  서경률  ;  이형근  ;  김응권  ;  김태임 
Citation
 Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.55(7) : 978-983, 2014 
Journal Title
 Journal of the Korean Ophthalmological Society  (대한안과학회지) 
ISSN
 0378-6471 
Issue Date
2014
Abstract
Purpose: To evaluate the efficacy of 0.05% cyclosporine A on tear film parameters and corneal aberration after cataract surgery. Methods: Patients who underwent cataract surgery were divided into 2 groups. Patients in Group I (23 eyes) were treated with cyclosporine A from 1 week before surgery to 3 months after surgery. Patients in Group II (24 eyes) underwent surgery without cyclosporine treatment. Tear film break-up time (BUT), Schirmer’s test I, Oxford scheme, Ocular surface disease index (OSDI), and corneal aberrations were evaluated before surgery and at 1 and 3 months after surgery. Results: In Group I, BUT was significantly improved at 3 months (p = 0.026) after surgery compared with the preoperative value. OSDI decreased significantly at 1 (p = 0.033) and 3 months (p = 0.003) after surgery compared with the preoperative value. However, there were no significant differences between preoperative and postoperative values of BUT and OSDI in Group II. Schirmer’s test results and the Oxford scheme were not significantly changed in either group. Preoperative root mean square (RMS) total values were not different between the 2 groups, but was different at postoperative 3 months (p = 0.015). Group I had a significantly lower value for total RMS than Group II. In Group I, Coma 7 (Z3-1) (p = 0.018) and spherical aberration (Z4 0) (p =0.031) were significantly decreased after surgery. In Group II, Trefoil 6 (Z3-3) (p = 0.033) was significantly increased after surgery. Conclusions: 0.05% cyclosporine A may be effective for improving dry eye syndrome and corneal aberration after cataract surgery.
Files in This Item:
T201403684.pdf Download
DOI
10.3341/jkos.2014.55.7.978
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Kim, Hong Seok(김홍석)
Seo, Kyuong Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Yoon, Sang Chul(윤상철) ORCID logo https://orcid.org/0000-0003-0454-9597
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
Jung, Ji Won(정지원)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100135
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