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Autophagy Activity in Pulmonary Metastatic Tumor Tissues from Colorectal Cancer: A Pilot Study

Authors
 Young Sam Kim  ;  Ju Hye Shin  ;  Mi Kyung Bae  ;  Chang Young Lee  ;  Dae Joon Kim  ;  Kyung Young Chung  ;  Jin Gu Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.55(6) : 1484-1488, 2014 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2014
MeSH
Adaptor Proteins, Signal Transducing ; Aged ; Autophagy* ; Biomarkers, Tumor/metabolism ; Blotting, Western ; Colorectal Neoplasms/metabolism* ; Colorectal Neoplasms/pathology* ; Female ; Humans ; Lung Neoplasms/metabolism* ; Lung Neoplasms/pathology* ; Male ; Microfilament Proteins/metabolism* ; Microscopy, Electron, Transmission ; Microtubule-Associated Proteins ; Middle Aged ; Neoplasm Recurrence, Local ; Pilot Projects ; Proteins ; Retrospective Studies ; Sequestosome-1 Protein ; Treatment Failure
Keywords
Colorectal cancer ; autophagy ; metastasis ; treatment failure
Abstract
PURPOSE: Autophagy has been reported to be involved in treatment failure in tumor. We aimed to evaluate autophagy activity in tumor tissue and compare them between the recurrence and non-recurrence groups. MATERIALS AND METHODS: We analyzed expressions of autophagy-related proteins in tumor tissues which were obtained from pulmonary metastases of colorectal cancer patients by Western blot. We also analyzed autophagosomes by transmission electron microscopy. RESULTS: Tumor tissues from recurrence group showed increased levels of LC3B-II, decreased levels of p62/SQSTM1, and also a marked accumulation of autophagosomes compared with tissues from non-recurrence group. CONCLUSION: The present study suggests that autophagy may be associated with treatment failure of metastatic colorectal cancer.
Files in This Item:
T201403634.pdf Download
DOI
10.3349/ymj.2014.55.6.1484
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Bae, Mi Kyung(배미경)
Shin, Ju Hye(신주혜)
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100099
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