Cited 8 times in
Autophagy Activity in Pulmonary Metastatic Tumor Tissues from Colorectal Cancer: A Pilot Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김대준 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 배미경 | - |
dc.contributor.author | 신주혜 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 이창영 | - |
dc.contributor.author | 정경영 | - |
dc.date.accessioned | 2015-01-06T17:30:09Z | - |
dc.date.available | 2015-01-06T17:30:09Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100099 | - |
dc.description.abstract | PURPOSE: Autophagy has been reported to be involved in treatment failure in tumor. We aimed to evaluate autophagy activity in tumor tissue and compare them between the recurrence and non-recurrence groups. MATERIALS AND METHODS: We analyzed expressions of autophagy-related proteins in tumor tissues which were obtained from pulmonary metastases of colorectal cancer patients by Western blot. We also analyzed autophagosomes by transmission electron microscopy. RESULTS: Tumor tissues from recurrence group showed increased levels of LC3B-II, decreased levels of p62/SQSTM1, and also a marked accumulation of autophagosomes compared with tissues from non-recurrence group. CONCLUSION: The present study suggests that autophagy may be associated with treatment failure of metastatic colorectal cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1484~1488 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adaptor Proteins, Signal Transducing | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Autophagy* | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Colorectal Neoplasms/metabolism* | - |
dc.subject.MESH | Colorectal Neoplasms/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms/metabolism* | - |
dc.subject.MESH | Lung Neoplasms/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microfilament Proteins/metabolism* | - |
dc.subject.MESH | Microscopy, Electron, Transmission | - |
dc.subject.MESH | Microtubule-Associated Proteins | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Pilot Projects | - |
dc.subject.MESH | Proteins | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Sequestosome-1 Protein | - |
dc.subject.MESH | Treatment Failure | - |
dc.title | Autophagy Activity in Pulmonary Metastatic Tumor Tissues from Colorectal Cancer: A Pilot Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Ju Hye Shin | - |
dc.contributor.googleauthor | Mi Kyung Bae | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Kyung Young Chung | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.identifier.doi | 10.3349/ymj.2014.55.6.1484 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00368 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01792 | - |
dc.contributor.localId | A02155 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03245 | - |
dc.contributor.localId | A03571 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 25323883 | - |
dc.subject.keyword | Colorectal cancer | - |
dc.subject.keyword | autophagy | - |
dc.subject.keyword | metastasis | - |
dc.subject.keyword | treatment failure | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Bae, Mi Kyung | - |
dc.contributor.alternativeName | Shin, Ju Hye | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.alternativeName | Lee, Chang Young | - |
dc.contributor.alternativeName | Chung, Kyung Young | - |
dc.contributor.affiliatedAuthor | Kim, Dae Joon | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Bae, Mi Kyung | - |
dc.contributor.affiliatedAuthor | Shin, Ju Hye | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Lee, Chang Young | - |
dc.contributor.affiliatedAuthor | Chung, Kyung Young | - |
dc.citation.volume | 55 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1484 | - |
dc.citation.endPage | 1488 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.55(6) : 1484-1488, 2014 | - |
dc.identifier.rimsid | 50138 | - |
dc.type.rims | ART | - |
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