Oxidative Stress for the Stroke : A Review of Mechanisms

Abstract

The aim of this study is to provide fundamental knowledge for the mechanism of oxidative stress in stroke. The collection of literatures in this study was performed through a biomedical database, Pubmed, Korean research information service system, Riss4U, a science and technical database, ScienceDirect and Internet. This study investigated the known mechanisms of oxidative stress in stroke through published literature reviews. Stroke is associated with the production of reactive oxygen species (ROS) after ischemia-reperfusion in prehospital emergency system, and the use of many antioxidants is being considered in order to reduce the pathological damage caused by ROS. To enhance the quality of prehospital practice, the emergency medical technicians need to understand the accurate mechanism of oxidative stress, identify the risk factors affecting the process of ROS production, and monitor the cellular balance in oxidation-reduction. Providing effective prehospital care reducing oxidative stress will reduce cerebral damage and improve the status of health. Very few studies related to molecular mechanisms on the development of CVA were conducted in health care service field including nursing, therefore, it is important to encourage and continue related researches in the fields.