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Mycobacterium bovis Bacillus Calmette-Guerin (BCG) and BCG-based Vaccines Against Tuberculosis

Authors
 Seung Bin Cha  ;  Sung Jae Shin 
Citation
 Journal of Bacteriology and Virology, Vol.44(3) : 236-243, 2014 
Journal Title
 Journal of Bacteriology and Virology 
ISSN
 1598-2467 
Issue Date
2014
MeSH
Animals ; Chromatography, Liquid/methods* ; Drug Interactions ; Drug Stability ; Female ; Isoflavones/blood* ; Isoflavones/pharmacokinetics* ; Limit of Detection ; Male ; Rats, Wistar ; Reproducibility of Results ; Rhodanine/analogs & derivatives* ; Rhodanine/blood ; Rhodanine/pharmacokinetics ; Tandem Mass Spectrometry/methods* ; Thiazolidines/blood* ; Thiazolidines/pharmacokinetics*
Keywords
Epalrestat ; UHPLC-MS/MS ; pharmacokinetic interaction ; puerarin ; rat plasma
Abstract
Tuberculosis (TB) is the second leading infectious cause of mortality worldwide with about two million deaths per year. The only licensed TB vaccine, Mycobacterium bovis bacillus Calmette-Guerin (BCG) shows limited protection efficacy suggesting an improved vaccination strategy is required. Recently, several TB vaccine candidates have entered clinical trials. These vaccine candidates are live mycobacterial vaccines designed to replace BCG or subunit vaccines designed to boost immunity induced by BCG. Vaccines with different strategy such as therapeutic vaccines, which can also be used in combination with drug therapy, are in the early stages of development to resolve latent TB or reactivation from the latent state. In this review, we discuss about development of BCG and BCG-based vaccines and further studies necessary for novel TB vaccine development to sterilize tuberculosis.
Files in This Item:
T201403387.pdf Download
DOI
10.4167/jbv.2014.44.3.236
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
Cha, Seung Bin(차승빈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99910
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