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Autophagy and redox status in carcinoma of an unknown primary.

 Ji-Ye Kim  ;  Do Hee Kim  ;  Woo Hee Jung  ;  Ja Seung Koo 
 TUMORI J, Vol.100(4) : 118-129, 2014 
Journal Title
Issue Date
Adult ; Aged ; Apoptosis Regulatory Proteins/analysis ; Autophagy* ; Beclin-1 ; Carrier Proteins/analysis ; Catalase/analysis ; Female ; Glutathione S-Transferase pi/analysis ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Membrane Proteins/analysis ; Microtubule-Associated Proteins/analysis ; Middle Aged ; Neoplasms, Unknown Primary/chemistry* ; Neoplasms, Unknown Primary/metabolism ; Neoplasms, Unknown Primary/pathology* ; Neoplasms, Unknown Primary/therapy ; Oxidation-Reduction* ; Predictive Value of Tests ; Proportional Hazards Models ; Superoxide Dismutase/analysis ; Thioredoxin-Disulfide Reductase/analysis
autophagy ; glutathione S-transferase π ; LC3A ; redox ; unknown primary carcinoma
AIM AND BACKGROUND: The purpose of the study was to investigate the role and clinical implications of autophagy and reactive oxygen species-related proteins in carcinoma of an unknown primary (CUP). METHODS AND STUDY DESIGN: Tissue microarray was constructed for a total of 77 CUP cases. Immunohistochemical stains conducted were as follows: autophagy-related beclin-1, LC3A, LC3B, and p62; redox-related catalase, thioredoxin reductase, glutathione S-transferase π, thioredoxin-interacting protein, and manganese superoxide dismutase. Immunohistochemical results were then related to their clinicopathologic parameters. RESULTS: The degree of LC3A expression showed a difference according to histologic subtype. In undifferentiated carcinoma, LC3A had the highest expression and adenocarcinoma had the lowest expression (P = 0.021). According to clinical subtype, there was a significant difference between LC3A and glutathione S-transferase π in expression. LC3A had the highest expression in single-organ types and the lowest in intermediate and carcinomatosis types (P = 0.003). Glutathione S-transferase π showed the highest expression in nodal-type tumors and the lowest in carcinomatosis types (P = 0.010). In univariate analysis, shorter overall survival was related to tumor glutathione S-transferase π negativity (P = 0.030). CONCLUSIONS: Different expression levels of the autophagy and reactive oxygen species-related proteins, LC3A and glutathione S-transferase π, were observed according to histologic and/or clinical subtype of carcinoma of an unknown primary.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Do Hee(김도희)
Jung, Woo Hee(정우희)
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